Gene description for LPCAT1
Gene name lysophosphatidylcholine acyltransferase 1
Gene symbol LPCAT1
Other names/aliases AYTL2
PFAAP3
lpcat
Species Homo sapiens
 Database cross references - LPCAT1
ExoCarta ExoCarta_79888
Entrez Gene 79888
HGNC 25718
MIM 610472
UniProt Q8NF37  
 LPCAT1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LPCAT1
Molecular Function
    1-alkylglycerophosphocholine O-acyltransferase activity GO:0047191 IEA
    1-acylglycerophosphocholine O-acyltransferase activity GO:0047184 ISS
    calcium ion binding GO:0005509 IEA
    1-alkylglycerophosphocholine O-acetyltransferase activity GO:0047192 IEA
    1-alkenylglycerophosphocholine O-acyltransferase activity GO:0047159 IEA
Biological Process
    retina development in camera-type eye GO:0060041 IEA
    small molecule metabolic process GO:0044281 TAS
    phosphatidic acid biosynthetic process GO:0006654 TAS
    phospholipid metabolic process GO:0006644 TAS
    cellular lipid metabolic process GO:0044255 TAS
    surfactant homeostasis GO:0043129 IEA
    triglyceride biosynthetic process GO:0019432 TAS
    phosphatidylglycerol acyl-chain remodeling GO:0036148 TAS
    negative regulation of phosphatidylcholine biosynthetic process GO:2001246 IEA
    glycerophospholipid biosynthetic process GO:0046474 TAS
    phosphatidylcholine acyl-chain remodeling GO:0036151 TAS
    phospholipid biosynthetic process GO:0008654 ISS
    positive regulation of protein catabolic process GO:0045732 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 ISS
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 IDA
    endoplasmic reticulum GO:0005783 ISS
    lipid particle GO:0005811 IDA
    Golgi membrane GO:0000139 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LPCAT1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LPCAT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LPCAT1 is involved
PathwayEvidenceSource
Acyl chain remodelling of PC TAS Reactome
Acyl chain remodelling of PG TAS Reactome
Synthesis of PA TAS Reactome
Triglyceride Biosynthesis TAS Reactome





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