Gene description for KLF2
Gene name Kruppel-like factor 2
Gene symbol KLF2
Other names/aliases LKLF
Species Homo sapiens
 Database cross references - KLF2
ExoCarta ExoCarta_10365
Entrez Gene 10365
HGNC 6347
MIM 602016
UniProt Q9Y5W3  
 KLF2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for KLF2
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    Type I pneumocyte differentiation GO:0060509 IEA
    cellular response to laminar fluid shear stress GO:0071499 IMP
    cellular response to hydrogen peroxide GO:0070301 IEA
    cellular response to cycloheximide GO:0071409 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
    transcription, DNA-templated GO:0006351 IEA
    cellular response to peptide GO:1901653 IEA
    erythrocyte maturation GO:0043249 IEA
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    in utero embryonic development GO:0001701 IEA
    positive regulation of protein metabolic process GO:0051247 IGI
    cell morphogenesis GO:0000902 IEA
    regulation of gene expression, epigenetic GO:0040029 IEA
    positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 IMP
    multicellular organism growth GO:0035264 IEA
    negative regulation of interleukin-6 production GO:0032715 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified KLF2 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KLF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WWP1 11059
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which KLF2 is involved
No pathways found

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