Gene description for C1RL
Gene name complement component 1, r subcomponent-like
Gene symbol C1RL
Other names/aliases C1RL1
C1RLP
C1r-LP
CLSPa
Species Homo sapiens
 Database cross references - C1RL
ExoCarta ExoCarta_51279
Vesiclepedia VP_51279
Entrez Gene 51279
HGNC 21265
MIM 608974
UniProt Q9NZP8  
 C1RL identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for C1RL
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
Biological Process
    complement activation, classical pathway GO:0006958 IEA
    zymogen activation GO:0031638 IBA
    innate immune response GO:0045087 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 IBA
 Experiment description of studies that identified C1RL in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for C1RL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 SPP1 6696
Two-hybrid Homo sapiens
3 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
4 C1R 715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PTBP3 9991
Affinity Capture-MS Homo sapiens
6 FBXO2 26232
Affinity Capture-MS Homo sapiens
7 FBXO6 26270
Affinity Capture-MS Homo sapiens
8 GUCA1B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which C1RL is involved
No pathways found





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