Gene description for PUM2
Gene name pumilio RNA-binding family member 2
Gene symbol PUM2
Other names/aliases PUMH2
PUML2
Species Homo sapiens
 Database cross references - PUM2
ExoCarta ExoCarta_23369
Vesiclepedia VP_23369
Entrez Gene 23369
HGNC 14958
MIM 607205
UniProt Q8TB72  
 PUM2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PUM2
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    mRNA 3'-UTR binding GO:0003730 TAS
    protein binding GO:0005515 IPI
    miRNA binding GO:0035198 IDA
    pumilio-response element binding GO:0062104 IEA
    lncRNA binding GO:0106222 IEA
Biological Process
    skeletal system development GO:0001501 IEA
    hair follicle development GO:0001942 IEA
    regulation of translation GO:0006417 IEA
    mitochondrion organization GO:0007005 IEA
    post-transcriptional regulation of gene expression GO:0010608 IDA
    post-transcriptional regulation of gene expression GO:0010608 IMP
    respiratory electron transport chain GO:0022904 IEA
    stress granule assembly GO:0034063 IEA
    miRNA processing GO:0035196 IBA
    miRNA processing GO:0035196 IMP
    regulation of mRNA stability GO:0043488 IBA
    regulation of mRNA stability GO:0043488 IDA
    positive regulation of sprouting of injured axon GO:0048687 IEA
    chromosome organization GO:0051276 IEA
    regulation of chromosome segregation GO:0051983 IDA
    adipose tissue development GO:0060612 IEA
    regulation of miRNA-mediated gene silencing GO:0060964 TAS
    3'-UTR-mediated mRNA destabilization GO:0061158 TAS
    regulation of postsynapse assembly GO:0150052 IEA
    positive regulation of RIG-I signaling pathway GO:1900246 IDA
    regulation of intracellular mRNA localization GO:1904580 IEA
    positive regulation of miRNA-mediated gene silencing GO:2000637 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IDA
    cytoplasmic stress granule GO:0010494 ISS
    nuclear membrane GO:0031965 IDA
    neuronal cell body GO:0043025 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified PUM2 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PUM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM120A 23196
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 NUPL2 11097
Affinity Capture-MS Homo sapiens
4 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PAIP2B  
Affinity Capture-MS Homo sapiens
6 HNRNPC 3183
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 RBM45  
Affinity Capture-MS Homo sapiens
9 SPSB4  
Affinity Capture-MS Homo sapiens
10 TP53 7157
Negative Genetic Homo sapiens
11 LARP4B 23185
Affinity Capture-MS Homo sapiens
12 MED4 29079
Two-hybrid Homo sapiens
13 LIN28A  
Affinity Capture-MS Homo sapiens
14 DAZL  
Two-hybrid Homo sapiens
15 RBM47 54502
Affinity Capture-MS Homo sapiens
16 CPEB1  
Proximity Label-MS Homo sapiens
17 APOBEC3D  
Affinity Capture-MS Homo sapiens
18 AURKA 6790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 RTP3  
Affinity Capture-MS Homo sapiens
20 NUFIP2 57532
Affinity Capture-MS Homo sapiens
21 FBXO45 200933
Affinity Capture-MS Homo sapiens
22 LITAF 9516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PUM2 23369
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
25 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
26 PARK2  
Affinity Capture-MS Homo sapiens
27 LOXL4 84171
Affinity Capture-MS Homo sapiens
28 CDX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 NUP35 129401
Proximity Label-MS Homo sapiens
30 MYC  
Affinity Capture-MS Homo sapiens
31 CELF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 YBX2 51087
Affinity Capture-MS Homo sapiens
33 MSI1  
Affinity Capture-MS Homo sapiens
34 ILF2 3608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PURG  
Affinity Capture-MS Homo sapiens
36 DAZ2  
Affinity Capture-MS Homo sapiens
37 DIABLO 56616
Proximity Label-MS Homo sapiens
38 RBFOX2 23543
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PTBP3 9991
Affinity Capture-MS Homo sapiens
40 GSPT2 23708
Affinity Capture-MS Homo sapiens
41 PSMA5 5686
Affinity Capture-MS Homo sapiens
42 PSMG3 84262
Affinity Capture-MS Homo sapiens
43 NTRK1 4914
Affinity Capture-MS Homo sapiens
44 DAZ1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
45 PABPC5 140886
Affinity Capture-MS Homo sapiens
46 CLASRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CBX6  
Affinity Capture-MS Homo sapiens
48 BMI1  
Affinity Capture-MS Homo sapiens
49 HECTD1 25831
Affinity Capture-MS Homo sapiens
50 GUSBP5  
Affinity Capture-MS Homo sapiens
51 OR13C3  
Affinity Capture-MS Homo sapiens
52 NANOS3  
Affinity Capture-Western Homo sapiens
53 STRBP 55342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 NANOS1 340719
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
55 AKAP1 8165
Proximity Label-MS Homo sapiens
56 RBMS2 5939
Affinity Capture-MS Homo sapiens
57 PAIP1 10605
Affinity Capture-MS Homo sapiens
58 BACE2 25825
Affinity Capture-MS Homo sapiens
59 SAMD1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PUM2 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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