Gene description for KCNS3
Gene name potassium voltage-gated channel, modifier subfamily S, member 3
Gene symbol KCNS3
Other names/aliases KV9.3
Species Homo sapiens
 Database cross references - KCNS3
ExoCarta ExoCarta_3790
Vesiclepedia VP_3790
Entrez Gene 3790
HGNC 6302
MIM 603888
UniProt Q9BQ31  
 KCNS3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for KCNS3
Molecular Function
    delayed rectifier potassium channel activity GO:0005251 TAS
    potassium channel regulator activity GO:0015459 IBA
    potassium channel regulator activity GO:0015459 ISS
Biological Process
    action potential GO:0001508 IBA
    potassium ion transport GO:0006813 TAS
    protein homooligomerization GO:0051260 IEA
    potassium ion transmembrane transport GO:0071805 IBA
    regulation of potassium ion transmembrane transport GO:1901379 ISS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    voltage-gated potassium channel complex GO:0008076 IBA
    membrane GO:0016020 IBA
 Experiment description of studies that identified KCNS3 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for KCNS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANKRD13C  
Affinity Capture-MS Homo sapiens
2 C2CD2L 9854
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SUCO  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 FAM189B  
Affinity Capture-MS Homo sapiens
5 SUN1 23353
Affinity Capture-MS Homo sapiens
6 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
7 C1orf43 25912
Affinity Capture-MS Homo sapiens
8 RHBDF2 79651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ZDHHC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PIGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 JPH1 56704
Affinity Capture-MS Homo sapiens
12 TYW1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KCNQ5  
Affinity Capture-MS Homo sapiens
14 EPHX1 2052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 HMGCR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PDE3B  
Affinity Capture-MS Homo sapiens
17 REEP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
20 PDZD8 118987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 GOLIM4 27333
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 VANGL2  
Affinity Capture-MS Homo sapiens
23 RETSAT 54884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DNAJC18  
Affinity Capture-MS Homo sapiens
25 TAOK2 9344
Affinity Capture-MS Homo sapiens
26 KCNB1  
Affinity Capture-Western Homo sapiens
27 ST7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 TAPT1 202018
Affinity Capture-MS Homo sapiens
29 KCNB2  
Affinity Capture-MS Homo sapiens
30 FNTB 2342
Affinity Capture-MS Homo sapiens
31 PNPLA6 10908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PLD6  
Affinity Capture-MS Homo sapiens
33 ATP2A3 489
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FIGNL1 63979
Affinity Capture-MS Homo sapiens
35 HCLS1 3059
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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