Gene description for KCNS3
Gene name potassium voltage-gated channel, modifier subfamily S, member 3
Gene symbol KCNS3
Other names/aliases KV9.3
Species Homo sapiens
 Database cross references - KCNS3
ExoCarta ExoCarta_3790
Entrez Gene 3790
HGNC 6302
MIM 603888
UniProt Q9BQ31  
 KCNS3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for KCNS3
Molecular Function
    delayed rectifier potassium channel activity GO:0005251 TAS
    potassium channel regulator activity GO:0015459 TAS
Biological Process
    synaptic transmission GO:0007268 TAS
    small molecule metabolic process GO:0044281 TAS
    potassium ion transport GO:0006813 TAS
    potassium ion transmembrane transport GO:0071805 IBA
    regulation of ion transmembrane transport GO:0034765 IEA
    protein homooligomerization GO:0051260 IEA
    energy reserve metabolic process GO:0006112 TAS
    regulation of insulin secretion GO:0050796 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IBA
    voltage-gated potassium channel complex GO:0008076 IEA
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified KCNS3 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for KCNS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNB1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which KCNS3 is involved
PathwayEvidenceSource
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion TAS Reactome
Voltage gated Potassium channels TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here