Gene description for PNPLA6
Gene name patatin-like phospholipase domain containing 6
Gene symbol PNPLA6
Other names/aliases BNHS
LNMS
NTE
NTEMND
OMCS
SPG39
iPLA2delta
sws
Species Homo sapiens
 Database cross references - PNPLA6
ExoCarta ExoCarta_10908
Entrez Gene 10908
HGNC 16268
MIM 603197
UniProt Q8IY17  
 PNPLA6 identified in exosomes derived from the following tissue/cell type
Urine 25452312    
 Gene ontology annotations for PNPLA6
Molecular Function
    lysophospholipase activity GO:0004622 IBA
Biological Process
    lipid catabolic process GO:0016042 IEA
    angiogenesis GO:0001525 IEA
    organ morphogenesis GO:0009887 IEA
    developmental process GO:0032502 IBA
    phosphatidylcholine metabolic process GO:0046470 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified PNPLA6 in exosomes
1
Experiment ID 238
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R.
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Filtration
Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PNPLA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PNPLA6 is involved
No pathways found





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