Gene description for Ppp6c
Gene name protein phosphatase 6, catalytic subunit
Gene symbol Ppp6c
Other names/aliases 2310003C10Rik
Species Mus musculus
 Database cross references - Ppp6c
ExoCarta ExoCarta_67857
Vesiclepedia VP_67857
Entrez Gene 67857
UniProt Q9CQR6  
 Ppp6c identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppp6c
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IBA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein serine/threonine phosphatase activity GO:0004722 ISO
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IBA
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 ISO
    innate immune response GO:0045087 IEA
    negative regulation of cGAS/STING signaling pathway GO:0160049 IEA
    negative regulation of cGAS/STING signaling pathway GO:0160049 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ppp6c in exosomes
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppp6c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGBP1 3476
Affinity Capture-MS Homo sapiens
2 DST 667
Affinity Capture-MS Homo sapiens
3 PPP6R3 55291
Affinity Capture-MS Homo sapiens
4 Pde4dip  
Affinity Capture-MS Mus musculus
5 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
6 CCT8 10694
Affinity Capture-MS Homo sapiens
7 CCT3 7203
Affinity Capture-MS Homo sapiens
8 CCT2 10576
Affinity Capture-MS Homo sapiens
9 Dlgap1  
Affinity Capture-MS Mus musculus
10 CCT6A 908
Affinity Capture-MS Homo sapiens
11 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
12 Atxn1  
Affinity Capture-MS Mus musculus
13 TCP1 6950
Affinity Capture-MS Homo sapiens
14 ARL6IP4  
Affinity Capture-MS Homo sapiens
15 Shank3  
Affinity Capture-MS Mus musculus
16 CCT4 10575
Affinity Capture-MS Homo sapiens
17 NOP9 161424
Affinity Capture-MS Homo sapiens
18 Chaf1a  
Affinity Capture-MS Mus musculus
19 PPP6R2 9701
Affinity Capture-MS Homo sapiens
20 DLGAP4 22839
Affinity Capture-MS Homo sapiens
21 ANKRD28 23243
Affinity Capture-MS Homo sapiens
22 PRKDC 5591
Affinity Capture-MS Homo sapiens
23 CCT7 10574
Affinity Capture-MS Homo sapiens
24 CCT5 22948
Affinity Capture-MS Homo sapiens
25 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
26 ANKRD44 91526
Affinity Capture-MS Homo sapiens
27 ANKRD52 283373
Affinity Capture-MS Homo sapiens
28 PRPF40B  
Affinity Capture-MS Homo sapiens
29 PTPMT1 114971
Affinity Capture-MS Homo sapiens
30 KIAA0391  
Affinity Capture-MS Homo sapiens
31 PGAP2  
Affinity Capture-MS Homo sapiens
32 USP42  
Affinity Capture-MS Homo sapiens
33 HERC4 26091
Affinity Capture-MS Homo sapiens
34 PPP6R1 22870
Affinity Capture-MS Homo sapiens
35 PNPLA6 10908
Affinity Capture-MS Homo sapiens
36 DDOST 1650
Affinity Capture-MS Homo sapiens
37 RAB26  
Affinity Capture-MS Homo sapiens
38 USP28 57646
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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