Gene description for SYNE3
Gene name spectrin repeat containing, nuclear envelope family member 3
Gene symbol SYNE3
Other names/aliases C14orf49
NET53
Nesp3
Species Homo sapiens
 Database cross references - SYNE3
ExoCarta ExoCarta_161176
Vesiclepedia VP_161176
Entrez Gene 161176
HGNC 19861
MIM 610861
UniProt Q6ZMZ3  
 SYNE3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SYNE3
Molecular Function
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IMP
    cytoskeleton-nuclear membrane anchor activity GO:0140444 IDA
Biological Process
    cytoskeleton organization GO:0007010 IMP
    nuclear migration GO:0007097 IBA
    regulation of cell shape GO:0008360 IMP
    establishment of protein localization to membrane GO:0090150 IDA
Subcellular Localization
    nuclear envelope GO:0005635 IDA
    nuclear outer membrane GO:0005640 IBA
    cytoplasm GO:0005737 IBA
    rough endoplasmic reticulum GO:0005791 IEA
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IDA
    meiotic nuclear membrane microtubule tethering complex GO:0034993 IBA
    meiotic nuclear membrane microtubule tethering complex GO:0034993 IDA
 Experiment description of studies that identified SYNE3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SYNE3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
2 DNAJC1 64215
Proximity Label-MS Homo sapiens
3 HSD17B11 51170
Proximity Label-MS Homo sapiens
4 FOXA1  
Affinity Capture-MS Homo sapiens
5 SSR1 6745
Proximity Label-MS Homo sapiens
6 STIM1 6786
Proximity Label-MS Homo sapiens
7 EMD 2010
Proximity Label-MS Homo sapiens
8 SEC62 7095
Proximity Label-MS Homo sapiens
9 DNAJC25 548645
Proximity Label-MS Homo sapiens
10 ELOVL5 60481
Proximity Label-MS Homo sapiens
11 TRIM21 6737
Affinity Capture-MS Homo sapiens
12 METTL7A 25840
Proximity Label-MS Homo sapiens
13 PRPF40A 55660
Affinity Capture-MS Homo sapiens
14 LINC00839  
Protein-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which SYNE3 is involved
No pathways found





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