Gene description for SALL1
Gene name spalt-like transcription factor 1
Gene symbol SALL1
Other names/aliases HEL-S-89
HSAL1
Sal-1
TBS
ZNF794
Species Homo sapiens
 Database cross references - SALL1
ExoCarta ExoCarta_6299
Vesiclepedia VP_6299
Entrez Gene 6299
HGNC 10524
MIM 602218
UniProt Q9NSC2  
 SALL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for SALL1
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    chromatin binding GO:0003682 IEA
    histone deacetylase activity GO:0004407 ISS
    DNA binding GO:0003677 NAS
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IDA
Biological Process
    histone deacetylation GO:0016575 ISS
    inductive cell-cell signaling GO:0031129 ISS
    hindlimb morphogenesis GO:0035137 IEA
    olfactory bulb interneuron differentiation GO:0021889 ISS
    forelimb morphogenesis GO:0035136 IEA
    ventricular septum development GO:0003281 ISS
    ureteric bud invasion GO:0072092 ISS
    outer ear morphogenesis GO:0042473 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    heart development GO:0007507 IMP
    mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 IEP
    transcription, DNA-templated GO:0006351 IEA
    limb development GO:0060173 IMP
    negative regulation of smoothened signaling pathway GO:0045879 IEA
    olfactory nerve development GO:0021553 ISS
    positive regulation of neuron differentiation GO:0045666 IEA
    ureteric bud development GO:0001657 ISS
    embryonic digit morphogenesis GO:0042733 IMP
    positive regulation of Wnt signaling pathway GO:0030177 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    adrenal gland development GO:0030325 IEP
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    embryonic digestive tract development GO:0048566 IMP
    neural tube closure GO:0001843 IEA
    gonad development GO:0008406 IEP
    olfactory bulb mitral cell layer development GO:0061034 IMP
    pituitary gland development GO:0021983 IEP
    regulation of neural precursor cell proliferation GO:2000177 IEA
    kidney development GO:0001822 IMP
    branching involved in ureteric bud morphogenesis GO:0001658 ISS
    kidney epithelium development GO:0072073 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    chromocenter GO:0010369 IDA
    NuRD complex GO:0016581 ISS
    heterochromatin GO:0000792 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SALL1 in exosomes
1
Experiment ID 236
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SALL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2I 7329
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 TERF1 7013
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 SUMO1 7341
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SALL1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here