Gene description for SALL1
Gene name spalt-like transcription factor 1
Gene symbol SALL1
Other names/aliases HEL-S-89
HSAL1
Sal-1
TBS
ZNF794
Species Homo sapiens
 Database cross references - SALL1
ExoCarta ExoCarta_6299
Vesiclepedia VP_6299
Entrez Gene 6299
HGNC 10524
MIM 602218
UniProt Q9NSC2  
 SALL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for SALL1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    ureteric bud development GO:0001657 ISS
    branching involved in ureteric bud morphogenesis GO:0001658 ISS
    kidney development GO:0001822 IMP
    ventricular septum development GO:0003281 ISS
    mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 IEP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    heart development GO:0007507 IMP
    gonad development GO:0008406 IEP
    olfactory nerve development GO:0021553 ISS
    olfactory bulb interneuron differentiation GO:0021889 ISS
    pituitary gland development GO:0021983 IEP
    positive regulation of Wnt signaling pathway GO:0030177 IDA
    adrenal gland development GO:0030325 IEP
    inductive cell-cell signaling GO:0031129 ISS
    embryonic digit morphogenesis GO:0042733 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    embryonic digestive tract development GO:0048566 IMP
    limb development GO:0060173 IMP
    olfactory bulb mitral cell layer development GO:0061034 IMP
    kidney epithelium development GO:0072073 ISS
    ureteric bud invasion GO:0072092 ISS
Subcellular Localization
    heterochromatin GO:0000792 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    chromocenter GO:0010369 IDA
 Experiment description of studies that identified SALL1 in exosomes
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SALL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DSN1 79980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GATAD2A 54815
Affinity Capture-MS Homo sapiens
3 SOX7  
Proximity Label-MS Homo sapiens
4 TLX1  
Proximity Label-MS Homo sapiens
5 TLX3  
Proximity Label-MS Homo sapiens
6 SALL2  
Affinity Capture-MS Homo sapiens
7 TIMM50 92609
Affinity Capture-MS Homo sapiens
8 FASN 2194
Negative Genetic Homo sapiens
9 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
10 CHD3 1107
Affinity Capture-MS Homo sapiens
11 HDAC2 3066
Affinity Capture-MS Homo sapiens
12 HPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 FEV  
Proximity Label-MS Homo sapiens
14 SALL4  
Affinity Capture-MS Homo sapiens
15 TRAF4 9618
Affinity Capture-MS Homo sapiens
16 MBD3 53615
Affinity Capture-MS Homo sapiens
17 MTA1 9112
Affinity Capture-MS Homo sapiens
18 KCNA4  
Affinity Capture-MS Homo sapiens
19 FOXJ2  
Affinity Capture-MS Homo sapiens
20 FOXB1  
Affinity Capture-MS Homo sapiens
21 GATA2  
Proximity Label-MS Homo sapiens
22 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FOXC1  
Affinity Capture-MS Homo sapiens
24 FOXG1  
Affinity Capture-MS Homo sapiens
25 NR3C1 2908
Proximity Label-MS Homo sapiens
26 SOX17  
Proximity Label-MS Homo sapiens
27 DCTN2 10540
Proximity Label-MS Homo sapiens
28 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CHD4 1108
Affinity Capture-MS Homo sapiens
30 VRTN  
Affinity Capture-MS Homo sapiens
31 MAGEA9  
Affinity Capture-MS Homo sapiens
32 SOX2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
33 MTA2 9219
Affinity Capture-MS Homo sapiens
34 PAX6  
Proximity Label-MS Homo sapiens
35 NFIX 4784
Proximity Label-MS Homo sapiens
36 GOLGA2 2801
Proximity Label-MS Homo sapiens
37 S100A6 6277
Affinity Capture-MS Homo sapiens
38 RFPL4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 UBE2I 7329
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
40 TERF1 7013
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
41 ADD2 119
Affinity Capture-MS Homo sapiens
42 GATAD2B 57459
Affinity Capture-MS Homo sapiens
43 FOXP1 27086
Affinity Capture-MS Homo sapiens
44 SLX4  
Affinity Capture-MS Homo sapiens
45 SALL3  
Affinity Capture-MS Homo sapiens
46 LHX3  
Proximity Label-MS Homo sapiens
47 FOXC2  
Affinity Capture-MS Homo sapiens
48 TEAD2  
Affinity Capture-MS Homo sapiens
49 MTA3 57504
Affinity Capture-MS Homo sapiens
50 S100B 6285
Affinity Capture-MS Homo sapiens
51 MBD2 8932
Affinity Capture-MS Homo sapiens
52 POU5F1  
Affinity Capture-MS Homo sapiens
53 SUMO1 7341
Two-hybrid Homo sapiens
54 NANOG  
Affinity Capture-MS Homo sapiens
55 FOXE1  
Affinity Capture-MS Homo sapiens
56 TEAD1  
Proximity Label-MS Homo sapiens
57 OSBPL1A 114876
Affinity Capture-MS Homo sapiens
58 RBBP4 5928
Affinity Capture-MS Homo sapiens
59 TEX19  
Affinity Capture-MS Homo sapiens
60 FOXA2  
Affinity Capture-MS Homo sapiens
61 C11orf31  
Affinity Capture-MS Homo sapiens
62 BCOR  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here