Gene description for PIR
Gene name pirin (iron-binding nuclear protein)
Gene symbol PIR
Other names/aliases -
Species Homo sapiens
 Database cross references - PIR
ExoCarta ExoCarta_8544
Entrez Gene 8544
HGNC 30048
MIM 300931
UniProt O00625  
 PIR identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PIR
Molecular Function
    quercetin 2,3-dioxygenase activity GO:0008127 IDA
    protein binding GO:0005515 IPI
    transcription cofactor activity GO:0003712 IMP
    metal ion binding GO:0046872 IDA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    oxidation-reduction process GO:0055114 IEA
    monocyte differentiation GO:0030224 IMP
    transcription from RNA polymerase II promoter GO:0006366 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified PIR in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PIR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCL3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 NFIX 4784
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 SMAD9  
Affinity Capture-MS Homo sapiens
4 NFKBIA  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PIR is involved
No pathways found





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