Gene description for NIPBL
Gene name	Nipped-B homolog (Drosophila)
Gene symbol	NIPBL
Other names/aliases	CDLS CDLS1 IDN3 IDN3-B Scc2
Species	Homo sapiens
Database cross references - NIPBL
ExoCarta	ExoCarta_25836
Vesiclepedia	VP_25836
Entrez Gene	25836
HGNC	28862
MIM	608667
UniProt	Q6KC79
NIPBL identified in exosomes derived from the following tissue/cell type
Plasma	19028452
Urine	19056867

Gene ontology annotations for NIPBL

Molecular Function     chromatin binding GO:0003682 IBA     transcription corepressor activity GO:0003714 IDA     protein binding GO:0005515 IPI     mediator complex binding GO:0036033 IEA     histone deacetylase binding GO:0042826 IPI     cohesin loader activity GO:0061775 IMP     chromo shadow domain binding GO:0070087 IPI     promoter-specific chromatin binding GO:1990841 ISS Biological Process     mitotic sister chromatid segregation GO:0000070 IEA     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     metanephros development GO:0001656 NAS     heart morphogenesis GO:0003007 IBA     heart morphogenesis GO:0003007 IMP     outflow tract morphogenesis GO:0003151 IMP     chromatin remodeling GO:0006338 IDA     DNA damage response GO:0006974 IMP     mitotic sister chromatid cohesion GO:0007064 IDA     mitotic sister chromatid cohesion GO:0007064 IMP     brain development GO:0007420 IBA     brain development GO:0007420 IMP     sensory perception of sound GO:0007605 IMP     protein localization GO:0008104 IMP     establishment of mitotic sister chromatid cohesion GO:0034087 IBA     maintenance of mitotic sister chromatid cohesion GO:0034088 IMP     somatic stem cell population maintenance GO:0035019 IEA     embryonic forelimb morphogenesis GO:0035115 IMP     forelimb morphogenesis GO:0035136 IMP     external genitalia morphogenesis GO:0035261 IMP     positive regulation of multicellular organism growth GO:0040018 IEA     ear morphogenesis GO:0042471 IMP     regulation of hair cycle GO:0042634 IMP     fat cell differentiation GO:0045444 IEA     positive regulation of ossification GO:0045778 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     regulation of embryonic development GO:0045995 IMP     embryonic digestive tract morphogenesis GO:0048557 IMP     digestive tract development GO:0048565 IBA     developmental growth GO:0048589 IMP     eye morphogenesis GO:0048592 IMP     regulation of developmental growth GO:0048638 IMP     embryonic viscerocranium morphogenesis GO:0048703 IBA     cognition GO:0050890 IMP     face morphogenesis GO:0060325 IMP     gallbladder development GO:0061010 IMP     uterus morphogenesis GO:0061038 IMP     establishment of protein localization to chromatin GO:0071169 IBA     cellular response to X-ray GO:0071481 IMP     replication-born double-strand break repair via sister chromatid exchange GO:1990414 IBA     positive regulation of neuron migration GO:2001224 ISS Subcellular Localization     chromatin GO:0000785 IEA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 IDA     integrator complex GO:0032039 ISS     SMC loading complex GO:0032116 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     extracellular exosome GO:0070062 HDA     Scc2-Scc4 cohesin loading complex GO:0090694 IBA     Scc2-Scc4 cohesin loading complex GO:0090694 IDA