Gene description for PRKCB
Gene name protein kinase C, beta
Gene symbol PRKCB
Other names/aliases PKC-beta
PKCB
PRKCB1
PRKCB2
Species Homo sapiens
 Database cross references - PRKCB
ExoCarta ExoCarta_5579
Vesiclepedia VP_5579
Entrez Gene 5579
HGNC 9395
MIM 176970
UniProt P05771  
 PRKCB identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for PRKCB
Molecular Function
    chromatin binding GO:0003682 IDA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 TAS
    diacylglycerol-dependent serine/threonine kinase activity GO:0004697 EXP
    diacylglycerol-dependent serine/threonine kinase activity GO:0004697 TAS
    calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IDA
    diacylglycerol-dependent, calcium-independent serine/threonine kinase activity GO:0004699 IEA
    protein kinase C binding GO:0005080 IPI
    calcium channel regulator activity GO:0005246 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    zinc ion binding GO:0008270 IEA
    nuclear receptor coactivator activity GO:0030374 IMP
    histone H3T6 kinase activity GO:0035403 IDA
    histone binding GO:0042393 IDA
    nuclear androgen receptor binding GO:0050681 IDA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    adaptive immune response GO:0002250 IEA
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IMP
    protein phosphorylation GO:0006468 TAS
    calcium ion transport GO:0006816 IEA
    intracellular calcium ion homeostasis GO:0006874 IEA
    apoptotic process GO:0006915 IEA
    mitotic nuclear membrane disassembly GO:0007077 TAS
    signal transduction GO:0007165 NAS
    phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway GO:0007207 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to glucose GO:0009749 IEA
    regulation of D-glucose transmembrane transport GO:0010827 IDA
    negative regulation of D-glucose transmembrane transport GO:0010829 ISS
    regulation of dopamine secretion GO:0014059 IEA
    dibenzo-p-dioxin metabolic process GO:0018894 IEA
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 ISS
    positive regulation of insulin secretion GO:0032024 IEA
    response to vitamin D GO:0033280 IEA
    intracellular signal transduction GO:0035556 IBA
    regulation of growth GO:0040008 IEA
    B cell activation GO:0042113 ISS
    positive regulation of odontogenesis of dentin-containing tooth GO:0042488 IEA
    lipoprotein transport GO:0042953 TAS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISS
    post-translational protein modification GO:0043687 IDA
    response to ethanol GO:0045471 IEA
    positive regulation of angiogenesis GO:0045766 ISS
    positive regulation of DNA-templated transcription GO:0045893 IEA
    negative regulation of insulin receptor signaling pathway GO:0046627 ISS
    B cell receptor signaling pathway GO:0050853 ISS
    cellular response to carbohydrate stimulus GO:0071322 IEA
    presynaptic modulation of chemical synaptic transmission GO:0099171 IEA
    regulation of synaptic vesicle exocytosis GO:2000300 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    spectrin GO:0008091 IEA
    brush border membrane GO:0031526 IEA
    calyx of Held GO:0044305 IEA
    extracellular exosome GO:0070062 HDA
    presynaptic cytosol GO:0099523 IEA
 Experiment description of studies that identified PRKCB in sEVs
1
Experiment ID 79
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
9
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKCB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SDC2 6383
Biochemical Activity Homo sapiens
2 ADRBK1 156
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 LSP1 4046
Affinity Capture-Western Homo sapiens
4 CHUK 1147
Co-localization Homo sapiens
5 ARRB2 409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 GNA12 2768
Biochemical Activity Homo sapiens
8 PPP2R4 5524
Biochemical Activity Homo sapiens
9 SHCBP1 79801
Affinity Capture-MS Homo sapiens
10 RDH14 57665
Affinity Capture-MS Homo sapiens
11 RASGRP3  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
12 PRKCD 5580
Affinity Capture-MS Homo sapiens
13 TIAM1  
Biochemical Activity Homo sapiens
14 MBD4  
Affinity Capture-MS Homo sapiens
15 LMNB1 4001
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
16 Marcks 17118
Biochemical Activity Mus musculus
17 SOGA3  
Affinity Capture-MS Homo sapiens
18 RNF31 55072
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 TRIM41 90933
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
20 PPP1CA 5499
Biochemical Activity Homo sapiens
21 IKBKG 8517
Reconstituted Complex Homo sapiens
22 NCAM1 4684
Affinity Capture-Western Homo sapiens
23 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
24 RGS2  
Biochemical Activity Homo sapiens
25 CARD11  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
26 EGFR 1956
Biochemical Activity Homo sapiens
27 GSK3B 2932
Co-localization Homo sapiens
28 H1F0 3005
Biochemical Activity Homo sapiens
29 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
30 PDPK1 5170
Reconstituted Complex Homo sapiens
31 DDX58 23586
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
32 RIPK4  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
33 CDK1 983
Affinity Capture-Western Homo sapiens
34 FN1 2335
Affinity Capture-MS Homo sapiens
35 GSK3A 2931
Biochemical Activity Homo sapiens
36 TERF1 7013
Two-hybrid Homo sapiens
37 TOP2A 7153
Biochemical Activity Homo sapiens
38 CSF2RB  
Affinity Capture-Western Homo sapiens
39 PDLIM5 10611
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
40 MAPT  
Biochemical Activity Homo sapiens
41 AFAP1 60312
Reconstituted Complex Homo sapiens
42 BLVRA 644
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
43 IBTK 25998
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
44 PRKCA 5578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 HSPA4 3308
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
46 HIST1H1A 3024
Biochemical Activity Homo sapiens
47 EP300 2033
Biochemical Activity Homo sapiens
48 ITGB3 3690
Affinity Capture-Western Homo sapiens
49 GNA13 10672
Biochemical Activity Homo sapiens
50 GNB2L1 10399
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
51 BTK 695
Reconstituted Complex Homo sapiens
52 YWHAG 7532
Affinity Capture-Western Homo sapiens
53 PRKCB 5579
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
54 NCF1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
55 TINF2  
Two-hybrid Homo sapiens
56 ITGB2 3689
Biochemical Activity Homo sapiens
57 IKBKB 3551
Co-localization Homo sapiens
58 HIST1H3A 8350
Biochemical Activity Homo sapiens
59 RBCK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 MBP 4155
Biochemical Activity Homo sapiens
61 KCNA5  
Affinity Capture-Western Homo sapiens
62 DEC1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRKCB is involved
PathwayEvidenceSource
Activation of NF-kappaB in B cells TAS Reactome
Adaptive Immune System TAS Reactome
Beta-catenin independent WNT signaling TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Depolymerization of the Nuclear Lamina TAS Reactome
Disinhibition of SNARE formation TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
G alpha (z) signalling events IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity TAS Reactome
GPCR downstream signalling IEA Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
M Phase TAS Reactome
Mitotic Prophase TAS Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Nuclear Envelope Breakdown TAS Reactome
PCP/CE pathway TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Response to elevated platelet cytosolic Ca2+ TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate NADPH Oxidases TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by VEGF TAS Reactome
Signaling by WNT TAS Reactome
Trafficking of AMPA receptors TAS Reactome
Trafficking of GluR2-containing AMPA receptors TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transmission across Chemical Synapses TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFR2 mediated cell proliferation TAS Reactome
WNT5A-dependent internalization of FZD4 TAS Reactome





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