Gene description for FES
Gene name FES proto-oncogene, tyrosine kinase
Gene symbol FES
Other names/aliases FPS
Species Homo sapiens
 Database cross references - FES
ExoCarta ExoCarta_2242
Entrez Gene 2242
HGNC 3657
MIM 190030
UniProt P07332  
 FES identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FES
Molecular Function
    immunoglobulin receptor binding GO:0034987 IDA
    protein tyrosine kinase activity GO:0004713 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IDA
    ATP binding GO:0005524 IEA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
Biological Process
    protein autophosphorylation GO:0046777 IDA
    chemotaxis GO:0006935 IBA
    regulation of cell adhesion GO:0030155 IMP
    cell differentiation GO:0030154 IBA
    cell proliferation GO:0008283 TAS
    axon guidance GO:0007411 TAS
    cell migration GO:0016477 IBA
    protein phosphorylation GO:0006468 TAS
    positive regulation of microtubule polymerization GO:0031116 IMP
    regulation of cell shape GO:0008360 IMP
    regulation of mast cell degranulation GO:0043304 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    regulation of cell differentiation GO:0045595 IMP
    positive regulation of actin cytoskeleton reorganization GO:2000251 IMP
    regulation of cell motility GO:2000145 IMP
    regulation of vesicle-mediated transport GO:0060627 TAS
    innate immune response GO:0045087 IBA
    peptidyl-tyrosine autophosphorylation GO:0038083 IBA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    positive regulation of myeloid cell differentiation GO:0045639 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    cell adhesion GO:0007155 IBA
    regulation of cell proliferation GO:0042127 IMP
    multicellular organismal development GO:0007275 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    microtubule cytoskeleton GO:0015630 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
    cytoplasmic vesicle GO:0031410 IDA
    cytoplasm GO:0005737 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    focal adhesion GO:0005925 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FES in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMD13 5719
Affinity Capture-MS Homo sapiens
2 HSPA4 3308
Reconstituted Complex Homo sapiens
3 RASA1 5921
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
4 PTGES3 10728
Reconstituted Complex Homo sapiens
5 IL4R  
Invivo Homo sapiens
6 BCAR1 9564
Invivo Homo sapiens
7 PIK3R1 5295
Invitro Homo sapiens
8 FKBP5 2289
Reconstituted Complex Homo sapiens
9 DPYSL5  
Affinity Capture-MS Homo sapiens
10 HSH2D 84941
Invivo Homo sapiens
Two-hybrid Homo sapiens
11 FKBP4 2288
Reconstituted Complex Homo sapiens
12 RASA3 22821
Invitro Homo sapiens
13 HSP90AA1 3320
Reconstituted Complex Homo sapiens
14 STAT3 6774
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 BCR 613
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 PPID 5481
Reconstituted Complex Homo sapiens
View the network image/svg+xml

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