Gene description for HSH2D
Gene name hematopoietic SH2 domain containing
Gene symbol HSH2D
Other names/aliases ALX
HSH2
Species Homo sapiens
 Database cross references - HSH2D
ExoCarta ExoCarta_84941
Vesiclepedia VP_84941
Entrez Gene 84941
HGNC 24920
MIM 608349
UniProt Q96JZ2  
 HSH2D identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for HSH2D
Molecular Function
    SH3/SH2 adaptor activity GO:0005070 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of mitochondrial depolarization GO:0051902 IEA
    negative regulation of B cell apoptotic process GO:0002903 IEA
    positive regulation of signal transduction GO:0009967 IEA
    T cell activation GO:0042110 IEA
Subcellular Localization
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified HSH2D in exosomes
1
Experiment ID 207
MISEV standards
EM
EV Biophysical techniques
TSG101|HSP70|FLOT1
EV Enriched markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
EV Biophysical techniques
TSG101|HSP70|FLOT1
EV Enriched markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
EV Biophysical techniques
TSG101|HSP70|FLOT1
EV Enriched markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSH2D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNK2 10188
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 FES 2242
Invivo Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HSH2D is involved
No pathways found





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