Gene description for HNMT
Gene name histamine N-methyltransferase
Gene symbol HNMT
Other names/aliases HMT
HNMT-S1
HNMT-S2
Species Homo sapiens
 Database cross references - HNMT
ExoCarta ExoCarta_3176
Entrez Gene 3176
HGNC 5028
MIM 605238
UniProt P50135  
 HNMT identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for HNMT
Molecular Function
    histamine N-methyltransferase activity GO:0046539 IBA
Biological Process
    methylation GO:0032259 IBA
    hyperosmotic response GO:0006972 IEA
    response to amine GO:0014075 IEA
    response to cocaine GO:0042220 IEA
    response to immobilization stress GO:0035902 IEA
    brain development GO:0007420 IBA
    response to interleukin-1 GO:0070555 IEA
    response to glucocorticoid GO:0051384 IEA
    response to tumor cell GO:0002347 IEA
    respiratory gaseous exchange GO:0007585 TAS
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
Subcellular Localization
    neuron projection GO:0043005 IBA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified HNMT in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for HNMT
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HNMT is involved
No pathways found





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