Gene description for HNMT
Gene name histamine N-methyltransferase
Gene symbol HNMT
Other names/aliases HMT
HNMT-S1
HNMT-S2
Species Homo sapiens
 Database cross references - HNMT
ExoCarta ExoCarta_3176
Vesiclepedia VP_3176
Entrez Gene 3176
HGNC 5028
MIM 605238
UniProt P50135  
 HNMT identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for HNMT
Molecular Function
    histamine N-methyltransferase activity GO:0046539 IDA
    histamine N-methyltransferase activity GO:0046539 TAS
Biological Process
    histamine metabolic process GO:0001692 IMP
    histamine catabolic process GO:0001695 IDA
    L-histidine catabolic process GO:0006548 TAS
    respiratory gaseous exchange by respiratory system GO:0007585 TAS
    methylation GO:0032259 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HNMT in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for HNMT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMK2D 817
Two-hybrid Homo sapiens
2 TERF1 7013
Two-hybrid Homo sapiens
3 TINF2  
Two-hybrid Homo sapiens
4 Tpm1 22003
Affinity Capture-MS Mus musculus
5 POT1  
Two-hybrid Homo sapiens
6 DSP 1832
Co-fractionation Homo sapiens
View the network image/svg+xml



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