Gene description for Tpm1
Gene name tropomyosin 1, alpha
Gene symbol Tpm1
Other names/aliases AA986836
AI854628
TM2
Tm3
Tmpa
Tpm-1
alpha-TM
Species Mus musculus
 Database cross references - Tpm1
ExoCarta ExoCarta_22003
Entrez Gene 22003
UniProt P58771  
 Tpm1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tpm1
Molecular Function
    actin binding GO:0003779 ISO
    protein N-terminus binding GO:0047485 ISO
    protein homodimerization activity GO:0042803 ISO
    structural constituent of cytoskeleton GO:0005200 TAS
    actin filament binding GO:0051015 ISO
Biological Process
    positive regulation of ATPase activity GO:0032781 ISO
    ruffle organization GO:0031529 ISO
    actin filament capping GO:0051693 ISO
    in utero embryonic development GO:0001701 IMP
    positive regulation of heart rate by epinephrine GO:0003065 IMP
    negative regulation of cell migration GO:0030336 ISO
    wound healing GO:0042060 ISO
    embryo development GO:0009790 IMP
    cardiac muscle contraction GO:0060048 ISO
    positive regulation of cell adhesion GO:0045785 ISO
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    positive regulation of stress fiber assembly GO:0051496 ISO
    muscle filament sliding GO:0030049 ISO
    regulation of ATPase activity GO:0043462 ISO
Subcellular Localization
    muscle thin filament tropomyosin GO:0005862 TAS
    filamentous actin GO:0031941 IDA
    protein complex GO:0043234 ISO
    myofibril GO:0030016 IDA
    cytoskeleton GO:0005856 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Tpm1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tpm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tpm1 is involved
PathwayEvidenceSource
Smooth Muscle Contraction IEA Reactome
Striated Muscle Contraction IEA Reactome





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