Gene description for CDK13
Gene name cyclin-dependent kinase 13
Gene symbol CDK13
Other names/aliases CDC2L
CDC2L5
CHED
hCDK13
Species Homo sapiens
 Database cross references - CDK13
ExoCarta ExoCarta_8621
Entrez Gene 8621
HGNC 1733
MIM 603309
UniProt Q14004  
 CDK13 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CDK13
Molecular Function
    protein kinase activity GO:0004672 TAS
    poly(A) RNA binding GO:0044822 IDA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA
    cyclin binding GO:0030332 IPI
    ATP binding GO:0005524 IEA
    RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 IDA
    protein binding GO:0005515 IPI
Biological Process
    alternative mRNA splicing, via spliceosome GO:0000380 TAS
    phosphorylation of RNA polymerase II C-terminal domain GO:0070816 IDA
    positive regulation of cell proliferation GO:0008284 TAS
    regulation of mitotic nuclear division GO:0007088 TAS
    multicellular organismal development GO:0007275 TAS
    hemopoiesis GO:0030097 IMP
    viral process GO:0016032 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cyclin K-CDK13 complex GO:0002945 IPI
    Golgi apparatus GO:0005794 IDA
    nuclear speck GO:0016607 IDA
    extracellular space GO:0005615 IDA
    nucleoplasm GO:0005654 IDA
    nuclear cyclin-dependent protein kinase holoenzyme complex GO:0019908 ISS
 Experiment description of studies that identified CDK13 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CDK13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRPF40A 55660
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDK13 is involved
No pathways found





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