Gene description for RASGEF1C
Gene name RasGEF domain family, member 1C
Gene symbol RASGEF1C
Other names/aliases -
Species Homo sapiens
 Database cross references - RASGEF1C
ExoCarta ExoCarta_255426
Vesiclepedia VP_255426
Entrez Gene 255426
HGNC 27400
UniProt Q8N431  
 RASGEF1C identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RASGEF1C
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
Biological Process
    Ras protein signal transduction GO:0007265 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified RASGEF1C in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RASGEF1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 S100A7A 338324
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TERF1 7013
Affinity Capture-MS Homo sapiens
3 CUL7 9820
Affinity Capture-MS Homo sapiens
4 POT1  
Affinity Capture-MS Homo sapiens
5 TERF2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RASGEF1C is involved
No pathways found





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