Gene description for RASGEF1C
Gene name RasGEF domain family, member 1C
Gene symbol RASGEF1C
Other names/aliases -
Species Homo sapiens
 Database cross references - RASGEF1C
ExoCarta ExoCarta_255426
Entrez Gene 255426
HGNC 27400
UniProt Q8N431  
 RASGEF1C identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RASGEF1C
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    small GTPase mediated signal transduction GO:0007264 IEA
Subcellular Localization
    intracellular GO:0005622 IEA
 Experiment description of studies that identified RASGEF1C in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RASGEF1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RASGEF1C is involved
No pathways found





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