Gene description for DLG5
Gene name discs, large homolog 5 (Drosophila)
Gene symbol DLG5
Other names/aliases LP-DLG
Species Homo sapiens
 Database cross references - DLG5
ExoCarta ExoCarta_9231
Entrez Gene 9231
HGNC 2904
MIM 604090
UniProt Q8TDM6  
 DLG5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DLG5
Molecular Function
    protein binding GO:0005515 IPI
    receptor signaling complex scaffold activity GO:0030159 NAS
    cytoskeletal protein binding GO:0008092 IDA
    beta-catenin binding GO:0008013 IDA
Biological Process
    regulation of apoptotic process GO:0042981 IEA
    epithelial tube branching involved in lung morphogenesis GO:0060441 IEA
    signal transduction GO:0007165 TAS
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IEA
    intracellular signal transduction GO:0035556 NAS
    negative regulation of cell proliferation GO:0008285 TAS
    protein localization to adherens junction GO:0071896 IEA
    single organismal cell-cell adhesion GO:0016337 NAS
    midbrain development GO:0030901 IEA
    metanephric collecting duct development GO:0072205 IEA
    apical protein localization GO:0045176 IEA
    protein complex assembly GO:0006461 IEA
    polarized epithelial cell differentiation GO:0030859 IEA
    zonula adherens assembly GO:0045186 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 TAS
    cell-cell adherens junction GO:0005913 IEA
 Experiment description of studies that identified DLG5 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DLG5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PFN1 5216
Two-hybrid Homo sapiens
2 SORBS3 10174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 CTNNB1 1499
Affinity Capture-Western Homo sapiens
4 TERF1 7013
Two-hybrid Homo sapiens
5 CD81 975
Two-hybrid Homo sapiens
6 BTBD10 84280
Two-hybrid Homo sapiens
7 DLST 1743
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DLG5 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here