Gene description for ANXA8L1
Gene name annexin A8-like 1
Gene symbol ANXA8L1
Other names/aliases ANXA8
ANXA8L2
VAC-beta
bA145E20.2
Species Homo sapiens
 Database cross references - ANXA8L1
ExoCarta ExoCarta_728113
Vesiclepedia VP_728113
Entrez Gene 728113
HGNC 23334
UniProt P13928   Q5VT79  
 ANXA8L1 identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for ANXA8L1
Molecular Function
    phosphatidylserine binding GO:0001786 IBA
    calcium ion binding GO:0005509 IEA
    calcium-dependent phospholipid binding GO:0005544 IBA
Biological Process
    endosome organization GO:0007032 IBA
    endosomal transport GO:0016197 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    vesicle membrane GO:0012506 IBA
    sarcolemma GO:0042383 IBA
 Experiment description of studies that identified ANXA8L1 in exosomes
1
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ANXA8L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACD  
Two-hybrid Homo sapiens
2 RDH12 145226
Two-hybrid Homo sapiens
3 Cdk1 12534
Affinity Capture-MS Mus musculus
4 TERF1 7013
Two-hybrid Homo sapiens
5 TINF2  
Two-hybrid Homo sapiens
6 CDK15  
Affinity Capture-MS Homo sapiens
7 LMNA 4000
Proximity Label-MS Homo sapiens
8 TERF2IP 54386
Two-hybrid Homo sapiens
9 UCHL5 51377
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ANXA8L1 is involved
No pathways found





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