Gene description for SLC6A4
Gene name	solute carrier family 6 (neurotransmitter transporter), member 4
Gene symbol	SLC6A4
Other names/aliases	5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT
Species	Homo sapiens
Database cross references - SLC6A4
ExoCarta	ExoCarta_6532
Vesiclepedia	VP_6532
Entrez Gene	6532
HGNC	11050
MIM	182138
UniProt	P31645
SLC6A4 identified in sEVs derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for SLC6A4

Molecular Function     integrin binding GO:0005178 IDA     monoatomic cation channel activity GO:0005261 ISS     neurotransmitter transmembrane transporter activity GO:0005326 ISS     serotonin:sodium:chloride symporter activity GO:0005335 IBA     serotonin:sodium:chloride symporter activity GO:0005335 IDA     serotonin:sodium:chloride symporter activity GO:0005335 IMP     serotonin:sodium:chloride symporter activity GO:0005335 TAS     protein binding GO:0005515 IPI     monoamine transmembrane transporter activity GO:0008504 IDA     monoamine transmembrane transporter activity GO:0008504 ISS     antiporter activity GO:0015297 IDA     syntaxin-1 binding GO:0017075 IEA     cocaine binding GO:0019811 IEA     sodium ion binding GO:0031402 IDA     identical protein binding GO:0042802 ISS     nitric-oxide synthase binding GO:0050998 IEA     actin filament binding GO:0051015 ISS     serotonin binding GO:0051378 IBA     serotonin binding GO:0051378 IDA Biological Process     response to hypoxia GO:0001666 IEA     neurotransmitter transport GO:0006836 ISS     amino acid transport GO:0006865 IBA     response to nutrient GO:0007584 IEA     memory GO:0007613 IEA     circadian rhythm GO:0007623 IEA     response to xenobiotic stimulus GO:0009410 IEA     response to toxic substance GO:0009636 IDA     positive regulation of gene expression GO:0010628 IEA     positive regulation of serotonin secretion GO:0014064 IEA     monoamine transport GO:0015844 IDA     negative regulation of cerebellar granule cell precursor proliferation GO:0021941 IEA     negative regulation of synaptic transmission, dopaminergic GO:0032227 IEA     response to estradiol GO:0032355 IEA     sodium ion transmembrane transport GO:0035725 IBA     vasoconstriction GO:0042310 IEA     sperm ejaculation GO:0042713 IEA     negative regulation of neuron differentiation GO:0045665 IEA     positive regulation of cell cycle GO:0045787 IEA     negative regulation of organ growth GO:0046621 IEA     behavioral response to cocaine GO:0048148 IEA     enteric nervous system development GO:0048484 IEA     brain morphogenesis GO:0048854 IEA     serotonin uptake GO:0051610 IBA     serotonin uptake GO:0051610 IDA     serotonin uptake GO:0051610 IMP     serotonin uptake GO:0051610 ISS     serotonin uptake GO:0051610 TAS     membrane depolarization GO:0051899 ISS     platelet aggregation GO:0070527 ISS     cellular response to retinoic acid GO:0071300 IEA     cellular response to cGMP GO:0071321 IEA     regulation of thalamus size GO:0090067 IMP     conditioned place preference GO:1990708 IEA Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     focal adhesion GO:0005925 ISS     endosome membrane GO:0010008 IEA     endomembrane system GO:0012505 IDA     presynaptic membrane GO:0042734 IEA     neuron projection GO:0043005 IBA     membrane raft GO:0045121 IDA     synapse GO:0045202 IBA     synapse GO:0045202 ISS     postsynaptic membrane GO:0045211 IEA     serotonergic synapse GO:0099154 IEA