Gene description for SLC6A4
Gene name solute carrier family 6 (neurotransmitter transporter), member 4
Gene symbol SLC6A4
Other names/aliases 5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
Species Homo sapiens
 Database cross references - SLC6A4
ExoCarta ExoCarta_6532
Vesiclepedia VP_6532
Entrez Gene 6532
HGNC 11050
MIM 182138
UniProt P31645  
 SLC6A4 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SLC6A4
Molecular Function
    cocaine binding GO:0019811 IEA
    protein homodimerization activity GO:0042803 IEA
    monoamine transmembrane transporter activity GO:0008504 IDA
    serotonin:sodium symporter activity GO:0005335 IMP
    nitric-oxide synthase binding GO:0050998 IEA
    syntaxin-1 binding GO:0017075 IEA
    actin filament binding GO:0051015 ISS
    serotonin transmembrane transporter activity GO:0015222 IMP
    Rab GTPase binding GO:0017137 IPI
    protein binding GO:0005515 IPI
    myosin binding GO:0017022 IEA
Biological Process
    response to hypoxia GO:0001666 IEA
    response to drug GO:0042493 IEA
    negative regulation of neuron differentiation GO:0045665 IEA
    cellular response to cGMP GO:0071321 IEA
    response to estradiol GO:0032355 IEA
    cellular response to retinoic acid GO:0071300 IEA
    positive regulation of gene expression GO:0010628 IEA
    thalamus development GO:0021794 IMP
    negative regulation of organ growth GO:0046621 ISS
    memory GO:0007613 IEA
    monoamine transport GO:0015844 IDA
    negative regulation of synaptic transmission, dopaminergic GO:0032227 IEA
    transmembrane transport GO:0055085 IEA
    brain morphogenesis GO:0048854 ISS
    positive regulation of cell cycle GO:0045787 IEA
    serotonin transport GO:0006837 IDA
    circadian rhythm GO:0007623 IEA
    sperm ejaculation GO:0042713 IEA
    vasoconstriction GO:0042310 IEA
    response to nutrient GO:0007584 IEA
    response to toxic substance GO:0009636 IDA
    social behavior GO:0035176 ISS
    negative regulation of cerebellar granule cell precursor proliferation GO:0021941 IEA
    protein homooligomerization GO:0051260 IEA
    protein oligomerization GO:0051259 ISS
    serotonin uptake GO:0051610 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    neuron projection GO:0043005 IEA
    membrane raft GO:0045121 IDA
    endomembrane system GO:0012505 IDA
    endosome membrane GO:0010008 IEA
    plasma membrane GO:0005886 IDA
    integral component of plasma membrane GO:0005887 IC
 Experiment description of studies that identified SLC6A4 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix|CD63|CD9
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC6A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX1A 6804
Affinity Capture-Western Homo sapiens
2 CALR 811
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SLC6A4 is involved
No pathways found





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