Gene description for CCNI
Gene name cyclin I
Gene symbol CCNI
Other names/aliases CCNI1
CYC1
CYI
Species Homo sapiens
 Database cross references - CCNI
ExoCarta ExoCarta_10983
Vesiclepedia VP_10983
Entrez Gene 10983
HGNC 1595
UniProt Q14094  
 CCNI identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for CCNI
Molecular Function
    protein binding GO:0005515 IPI
    cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IBA
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IBA
    spermatogenesis GO:0007283 NAS
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IBA
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified CCNI in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for CCNI
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NXF1 10482
Affinity Capture-RNA Homo sapiens
2 KRT18 3875
Two-hybrid Homo sapiens
3 CDC25A  
Two-hybrid Homo sapiens
4 ZMYND19  
Two-hybrid Homo sapiens
5 DDX58 23586
Affinity Capture-RNA Homo sapiens
6 CCNI2  
Negative Genetic Homo sapiens
7 CDK3 1018
Two-hybrid Homo sapiens
8 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
9 IL1RAP 3556
Two-hybrid Homo sapiens
10 CEP63  
Two-hybrid Homo sapiens
11 CDK5 1020
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 CDK6 1021
Two-hybrid Homo sapiens
13 MSRA 4482
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CCNI is involved
No pathways found





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