Gene description for MLLT1
Gene name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
Gene symbol MLLT1
Other names/aliases ENL
LTG19
YEATS1
Species Homo sapiens
 Database cross references - MLLT1
ExoCarta ExoCarta_4298
Vesiclepedia VP_4298
Entrez Gene 4298
HGNC 7134
MIM 159556
UniProt Q03111  
 MLLT1 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MLLT1
Molecular Function
    chromatin binding GO:0003682 IBA
    protein binding GO:0005515 IPI
    lysine-acetylated histone binding GO:0070577 IBA
Biological Process
    positive regulation of DNA-templated transcription GO:0045893 IBA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    transcription elongation factor complex GO:0008023 IBA
    transcription elongation factor complex GO:0008023 IDA
 Experiment description of studies that identified MLLT1 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MLLT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 ELL2 22936
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 CAMKV 79012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PLCD4  
Affinity Capture-MS Homo sapiens
5 SKP1 6500
Affinity Capture-MS Homo sapiens
6 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 EPB41L1 2036
Affinity Capture-MS Homo sapiens
8 WDR5 11091
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
9 PARP1 142
Proximity Label-MS Homo sapiens
10 YAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 COIL  
Proximity Label-MS Homo sapiens
12 KMT2A  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
13 CEP89 84902
Affinity Capture-MS Homo sapiens
14 CDK9 1025
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 EGLN3  
Affinity Capture-MS Homo sapiens
16 CHD1 1105
Affinity Capture-MS Homo sapiens
17 EPB41L3 23136
Affinity Capture-MS Homo sapiens
18 RFX5 5993
Affinity Capture-MS Homo sapiens
19 FGF12  
Affinity Capture-MS Homo sapiens
20 HTATSF1 27336
Co-fractionation Homo sapiens
21 S100A2 6273
Affinity Capture-MS Homo sapiens
22 NOP56 10528
Proximity Label-MS Homo sapiens
23 RAB3IL1 5866
Affinity Capture-MS Homo sapiens
24 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
25 PLEKHJ1  
Affinity Capture-MS Homo sapiens
26 AFF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 EPB41L2 2037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CCNT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
29 ACACA 31
Affinity Capture-MS Homo sapiens
30 POLR2A 5430
Affinity Capture-Western Homo sapiens
31 SOX2  
Affinity Capture-MS Homo sapiens
32 DOT1L 84444
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
34 CENPA  
Proximity Label-MS Homo sapiens
35 HAL 3034
Affinity Capture-MS Homo sapiens
36 ARID4A  
Affinity Capture-MS Homo sapiens
37 TRIM24  
Affinity Capture-MS Homo sapiens
38 ELL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ELL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DDX23 9416
Proximity Label-MS Homo sapiens
41 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 Dot1l  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
43 SP110  
Affinity Capture-MS Homo sapiens
44 YIF1A 10897
Two-hybrid Homo sapiens
45 DENND2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SPPL2B 56928
Affinity Capture-MS Homo sapiens
47 AFF4 27125
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
48 EAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CBX8 57332
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
50 MLLT10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 BPIFB1 92747
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PLCD3 113026
Affinity Capture-MS Homo sapiens
53 CCNT2  
Affinity Capture-MS Homo sapiens
54 MLLT3 4300
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
55 RFXAP  
Affinity Capture-MS Homo sapiens
56 PCGF1 84759
Affinity Capture-MS Homo sapiens
57 ARID4B  
Affinity Capture-MS Homo sapiens
58 ARID1A 8289
Co-fractionation Homo sapiens
59 ACTL6A 86
Co-fractionation Homo sapiens
60 POLR1E  
Proximity Label-MS Homo sapiens
61 PAF1 54623
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
62 SIRT1  
Affinity Capture-MS Homo sapiens
63 SERPINA12  
Affinity Capture-MS Homo sapiens
64 SYT2  
Affinity Capture-MS Homo sapiens
65 SP7  
Proximity Label-MS Homo sapiens
66 AFF3  
Affinity Capture-MS Homo sapiens
67 Aff1  
Affinity Capture-MS Mus musculus
68 RYBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MLLT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 BRD4 23476
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
71 BCOR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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