Gene description for FCN1
Gene name ficolin (collagen/fibrinogen domain containing) 1
Gene symbol FCN1
Other names/aliases FCNM
Species Homo sapiens
 Database cross references - FCN1
ExoCarta ExoCarta_2219
Entrez Gene 2219
HGNC 3623
MIM 601252
UniProt O00602  
 FCN1 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for FCN1
Molecular Function
    signaling pattern recognition receptor activity GO:0008329 IMP
    G-protein coupled receptor binding GO:0001664 IPI
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
    metal ion binding GO:0046872 IEA
    sialic acid binding GO:0033691 IDA
Biological Process
    positive regulation of interleukin-8 secretion GO:2000484 IMP
    negative regulation of viral entry into host cell GO:0046597 IDA
    recognition of apoptotic cell GO:0043654 IDA
    G-protein coupled receptor signaling pathway GO:0007186 IDA
    cell surface pattern recognition receptor signaling pathway GO:0002752 IMP
    innate immune response GO:0045087 TAS
    complement activation, lectin pathway GO:0001867 TAS
    protein localization to cell surface GO:0034394 IDA
    complement activation GO:0006956 TAS
Subcellular Localization
    extrinsic component of external side of plasma membrane GO:0031232 IDA
    collagen trimer GO:0005581 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified FCN1 in exosomes
1
Experiment ID 44
ISEV standards
IEM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for FCN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ELN  
Invitro Homo sapiens
2 TGFB1 7040
Co-purification Homo sapiens
View the network image/svg+xml



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