Gene description for FCN2
Gene name ficolin (collagen/fibrinogen domain containing lectin) 2
Gene symbol FCN2
Other names/aliases EBP-37
FCNL
P35
ficolin-2
Species Homo sapiens
 Database cross references - FCN2
ExoCarta ExoCarta_2220
Entrez Gene 2220
HGNC 3624
MIM 601624
UniProt Q15485  
 FCN2 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
Urine 19056867    
 Gene ontology annotations for FCN2
Molecular Function
    calcium-dependent protein binding GO:0048306 IPI
    protein binding GO:0005515 IPI
    antigen binding GO:0003823 IDA
    proteoglycan binding GO:0043394 IDA
    mannan binding GO:2001065 IDA
Biological Process
    opsonization GO:0008228 IDA
    recognition of apoptotic cell GO:0043654 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    innate immune response GO:0045087 TAS
    complement activation GO:0006956 TAS
    complement activation, lectin pathway GO:0001867 TAS
    defense response to Gram-negative bacterium GO:0050829 IDA
Subcellular Localization
    collagen trimer GO:0005581 IEA
    blood microparticle GO:0072562 IDA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified FCN2 in exosomes
1
Experiment ID 44
ISEV standards
✔
IEM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FCN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MASP1 5648
Invitro Homo sapiens
2 MASP2 10747
Invitro Homo sapiens
View the network image/svg+xml



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