Gene description for SIRPB1
Gene name signal-regulatory protein beta 1
Gene symbol SIRPB1
Other names/aliases CD172b
SIRP-BETA-1
Species Homo sapiens
 Database cross references - SIRPB1
ExoCarta ExoCarta_10326
Entrez Gene 10326
HGNC 15928
MIM 603889
UniProt Q5TFQ8   O00241  
 SIRPB1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for SIRPB1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 TAS
    innate immune response GO:0045087 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SIRPB1 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for SIRPB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TYROBP  
Invivo Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SIRPB1 is involved
PathwayEvidenceSource
DAP12 interactions TAS Reactome
Signal regulatory protein (SIRP) family interactions TAS Reactome





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