Gene description for EML2
Gene name echinoderm microtubule associated protein like 2
Gene symbol EML2
Other names/aliases ELP70
Species Homo sapiens
 Database cross references - EML2
ExoCarta ExoCarta_24139
Entrez Gene 24139
HGNC 18035
UniProt O95834  
 EML2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for EML2
Molecular Function
    tubulin binding GO:0015631 IDA
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
    protein C-terminus binding GO:0008022 IEA
    receptor binding GO:0005102 IEA
Biological Process
    sensory perception of sound GO:0007605 TAS
    visual perception GO:0007601 TAS
    negative regulation of microtubule polymerization GO:0031115 IDA
    regulation of microtubule nucleation GO:0010968 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microtubule GO:0005874 IEA
    microtubule associated complex GO:0005875 TAS
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified EML2 in exosomes
Experiment ID 234
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for EML2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NEK6 10783
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EML2 is involved
No pathways found

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