Gene description for XDH
Gene name	xanthine dehydrogenase
Gene symbol	XDH
Other names/aliases	XO XOR
Species	Homo sapiens
Database cross references - XDH
ExoCarta	ExoCarta_7498
Entrez Gene	7498
HGNC	12805
MIM	607633
UniProt	P47989
XDH identified in exosomes derived from the following tissue/cell type
Breast milk	17641064
Breast milk	17641064

Gene ontology annotations for XDH

Molecular Function     xanthine dehydrogenase activity GO:0004854 IDA     protein homodimerization activity GO:0042803 IPI     2 iron, 2 sulfur cluster binding GO:0051537 IDA     oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016903 IBA     xanthine oxidase activity GO:0004855 IDA     UDP-N-acetylmuramate dehydrogenase activity GO:0008762 IEA     iron ion binding GO:0005506 IEA     molybdopterin cofactor binding GO:0043546 IDA     flavin adenine dinucleotide binding GO:0050660 IDA     electron carrier activity GO:0009055 IEA Biological Process     small molecule metabolic process GO:0044281 TAS     nucleobase-containing small molecule metabolic process GO:0055086 TAS     negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IDA     lactation GO:0007595 IEA     negative regulation of vasculogenesis GO:2001213 IDA     negative regulation of gene expression GO:0010629 IDA     purine nucleobase metabolic process GO:0006144 TAS     positive regulation of p38MAPK cascade GO:1900745 IDA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA     negative regulation of endothelial cell differentiation GO:0045602 IDA     oxidation-reduction process GO:0055114 IEA     purine nucleotide catabolic process GO:0006195 TAS     negative regulation of protein phosphorylation GO:0001933 IDA     positive regulation of reactive oxygen species metabolic process GO:2000379 IDA     xanthine catabolic process GO:0009115 IDA     negative regulation of protein kinase B signaling GO:0051898 IDA     negative regulation of endothelial cell proliferation GO:0001937 IDA Subcellular Localization     extracellular space GO:0005615 IDA     peroxisome GO:0005777 IEA     cytosol GO:0005829 TAS