Gene description for Tle1
Gene name transducin-like enhancer of split 1, homolog of Drosophila E(spl)
Gene symbol Tle1
Other names/aliases C230057C06Rik
Estm14
Grg-1
Grg1
Tle4l
Species Mus musculus
 Database cross references - Tle1
ExoCarta ExoCarta_21885
Entrez Gene 21885
UniProt Q62440  
 Tle1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tle1
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II transcription corepressor activity GO:0001106 ISO
    transcription corepressor activity GO:0003714 IDA
    identical protein binding GO:0042802 ISO
    chromatin binding GO:0003682 IDA
    transcription factor binding GO:0008134 ISO
Biological Process
    regulation of transcription from RNA polymerase II promoter GO:0006357 IGI
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISO
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of anoikis GO:2000811 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    positive regulation of gene expression GO:0010628 ISO
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IDA
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    transcription from RNA polymerase II promoter GO:0006366 ISO
Subcellular Localization
    nucleolus GO:0005730 ISO
    transcription factor complex GO:0005667 IDA
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Tle1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tle1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Foxg1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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