Gene description for Runx1
Gene name runt related transcription factor 1
Gene symbol Runx1
Other names/aliases AML1
CBF-alpha-2
Cbfa2
Pebp2a2
Pebpa2b
Species Mus musculus
 Database cross references - Runx1
ExoCarta ExoCarta_12394
Entrez Gene 12394
 Runx1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Runx1
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 ISO
    protein heterodimerization activity GO:0046982 ISO
    transcription factor binding GO:0008134 ISO
    protein binding GO:0005515 IPI
    repressing transcription factor binding GO:0070491 IPI
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    core promoter binding GO:0001047 ISO
    protein homodimerization activity GO:0042803 ISO
    ATP binding GO:0005524 IEA
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISO
    regulatory region DNA binding GO:0000975 ISO
    calcium ion binding GO:0005509 ISO
    DNA binding GO:0003677 ISO
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    myeloid progenitor cell differentiation GO:0002318 IMP
    response to retinoic acid GO:0032526 IDA
    regulation of transcription, DNA-templated GO:0006355 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IBA
    behavioral response to pain GO:0048266 IMP
    liver development GO:0001889 IMP
    regulation of hair follicle cell proliferation GO:0071336 IMP
    hemopoiesis GO:0030097 TAS
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    skeletal system development GO:0001501 IMP
    hair follicle morphogenesis GO:0031069 IMP
    regulation of T cell anergy GO:0002667 IMP
    positive regulation of cell maturation GO:1903431 IMP
    positive regulation of interleukin-2 production GO:0032743 ISO
    neuron differentiation GO:0030182 IMP
    definitive hemopoiesis GO:0060216 IMP
    positive regulation of interferon-gamma production GO:0032729 IDA
    negative regulation of cell proliferation GO:0008285 IMP
    neuron development GO:0048666 IMP
    positive regulation of angiogenesis GO:0045766 IMP
    embryonic hemopoiesis GO:0035162 IMP
    central nervous system development GO:0007417 IMP
    myeloid cell differentiation GO:0030099 ISO
    negative regulation of granulocyte differentiation GO:0030853 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    in utero embryonic development GO:0001701 IMP
    positive regulation of progesterone secretion GO:2000872 ISO
    regulation of signal transduction GO:0009966 IMP
    transcription from RNA polymerase II promoter GO:0006366 IBA
    positive regulation of granulocyte differentiation GO:0030854 ISO
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    basement membrane GO:0005604 IDA
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Runx1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Runx1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Runx1 is involved
No pathways found





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