Gene description for Cdk6
Gene name cyclin-dependent kinase 6
Gene symbol Cdk6
Other names/aliases 5830411I20
AI504062
Crk2
Species Mus musculus
 Database cross references - Cdk6
ExoCarta ExoCarta_12571
Vesiclepedia VP_12571
Entrez Gene 12571
UniProt Q64261  
 Cdk6 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cdk6
Molecular Function
    protein binding GO:0005515 IPI
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    transferase activity GO:0016740 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    cyclin binding GO:0030332 ISO
    kinase activity GO:0016301 IDA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 ISO
    ATP binding GO:0005524 ISO
    nucleotide binding GO:0000166 IEA
    protein kinase activity GO:0004672 IEA
Biological Process
    cell division GO:0051301 IEA
    Notch signaling pathway GO:0007219 IGI
    cell cycle GO:0007049 IEA
    negative regulation of osteoblast differentiation GO:0045668 ISO
    cell differentiation GO:0030154 IEA
    negative regulation of cellular senescence GO:2000773 ISO
    negative regulation of epithelial cell proliferation GO:0050680 ISO
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of cell cycle GO:0045786 ISO
    cell dedifferentiation GO:0043697 ISO
    hematopoietic progenitor cell differentiation GO:0002244 IMP
    negative regulation of myeloid cell differentiation GO:0045638 ISO
    regulation of gene expression GO:0010468 ISO
    hemopoiesis GO:0030097 IMP
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    T cell differentiation in thymus GO:0033077 IMP
    hematopoietic stem cell differentiation GO:0060218 IMP
    regulation of cell proliferation GO:0042127 IEA
    positive regulation of fibroblast proliferation GO:0048146 ISO
    type B pancreatic cell development GO:0003323 ISO
    phosphorylation GO:0016310 IDA
    gliogenesis GO:0042063 ISO
    regulation of erythrocyte differentiation GO:0045646 ISO
    protein phosphorylation GO:0006468 ISO
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 ISO
    centrosome GO:0005813 ISO
    cytoskeleton GO:0005856 IEA
    ruffle GO:0001726 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    cell projection GO:0042995 IEA
 Experiment description of studies that identified Cdk6 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cdk6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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