Gene description for Ccnd2
Gene name cyclin D2
Gene symbol Ccnd2
Other names/aliases 2600016F06Rik
AI256817
BF642806
C86853
Vin-1
Vin1
cD2
Species Mus musculus
 Database cross references - Ccnd2
ExoCarta ExoCarta_12444
Entrez Gene 12444
UniProt P30280  
 Ccnd2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ccnd2
Molecular Function
    protein kinase binding GO:0019901 ISO
    protein binding GO:0005515 IPI
Biological Process
    cell cycle GO:0007049 IEA
    regulation of cell cycle GO:0051726 IMP
    G1/S transition of mitotic cell cycle GO:0000082 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of protein phosphorylation GO:0001934 ISO
    cell division GO:0051301 IEA
    positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 ISO
    positive regulation of epithelial cell proliferation GO:0050679 ISO
Subcellular Localization
    nuclear membrane GO:0031965 ISO
    cytosol GO:0005829 ISO
    membrane GO:0016020 IEA
    nucleolus GO:0005730 ISO
    chromatin GO:0000785 ISO
    nucleus GO:0005634 ISO
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Ccnd2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ccnd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ccnd2 is involved
No pathways found





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