Gene description for Prmt1
Gene name protein arginine N-methyltransferase 1
Gene symbol Prmt1
Other names/aliases 6720434D09Rik
AW214366
Hrmt1l2
Mrmt1
Species Mus musculus
 Database cross references - Prmt1
ExoCarta ExoCarta_15469
Vesiclepedia VP_15469
Entrez Gene 15469
UniProt Q9JIF0  
 Prmt1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Prmt1
Molecular Function
    lysine N-methyltransferase activity GO:0016278 IEA
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    P-methyltransferase activity GO:0051994 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    histone methyltransferase activity GO:0042054 ISO
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    protein-arginine omega-N asymmetric methyltransferase activity GO:0035242 ISO
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    tRNA methyltransferase activity GO:0008175 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    histone methyltransferase activity (H4-R3 specific) GO:0044020 ISO
    trimethylamine methyltransferase activity GO:0043834 IEA
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    protein-arginine N-methyltransferase activity GO:0016274 ISO
    methyltransferase activity GO:0008168 IEA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    protein methyltransferase activity GO:0008276 ISO
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    histone-arginine N-methyltransferase activity GO:0008469 ISO
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    monomethylamine methyltransferase activity GO:0043852 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    RNA methyltransferase activity GO:0008173 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    DNA-methyltransferase activity GO:0009008 IEA
    S-methyltransferase activity GO:0008172 IEA
    snoRNP binding GO:0030519 ISO
    [cytochrome c]-arginine N-methyltransferase activity GO:0016275 ISO
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    protein binding GO:0005515 IPI
    Se-methyltransferase activity GO:0051995 IEA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
    identical protein binding GO:0042802 ISO
    protein-arginine omega-N monomethyltransferase activity GO:0035241 ISO
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    rRNA methyltransferase activity GO:0008649 IEA
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    protein-lysine N-methyltransferase activity GO:0016279 IEA
    N-methyltransferase activity GO:0008170 ISO
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
    poly(A) RNA binding GO:0044822 ISO
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    transferase activity GO:0016740 IEA
    mRNA methyltransferase activity GO:0008174 IEA
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    O-methyltransferase activity GO:0008171 IEA
    C-methyltransferase activity GO:0008169 IEA
Biological Process
    peptidyl-arginine omega-N-methylation GO:0035247 ISO
    peptidyl-arginine N-methylation GO:0035246 IDA
    neuron projection development GO:0031175 ISO
    peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0019919 ISO
    regulation of transcription, DNA-templated GO:0006355 IBA
    histone methylation GO:0016571 ISO
    peptidyl-arginine methylation GO:0018216 ISO
    methylation GO:0032259 IEA
    protein methylation GO:0006479 ISO
    in utero embryonic development GO:0001701 IMP
    negative regulation of megakaryocyte differentiation GO:0045653 ISO
    histone H4-R3 methylation GO:0043985 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 IEA
    protein complex GO:0043234 ISO
 Experiment description of studies that identified Prmt1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD81|FLOT1
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Prmt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prmt1 is involved
PathwayEvidenceSource
RMTs methylate histone arginines IEA Reactome





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