Gene description for Nop56
Gene name NOP56 ribonucleoprotein
Gene symbol Nop56
Other names/aliases 2310044F10Rik
Nol5a
Species Mus musculus
 Database cross references - Nop56
ExoCarta ExoCarta_67134
Entrez Gene 67134
UniProt Q9D6Z1  
 Nop56 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Neural stem cells 25242146    
 Gene ontology annotations for Nop56
Molecular Function
    snoRNA binding GO:0030515 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    rRNA modification GO:0000154 IBA
    biological_process GO:0008150 ND
    ribosome biogenesis GO:0042254 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    small-subunit processome GO:0032040 IBA
    cytoplasm GO:0005737 IEA
    membrane GO:0016020 ISO
    small nucleolar ribonucleoprotein complex GO:0005732 ISO
    box C/D snoRNP complex GO:0031428 IBA
    nucleolus GO:0005730 ISO
    pre-snoRNP complex GO:0070761 ISO
    ribonucleoprotein complex GO:0030529 IEA
 Experiment description of studies that identified Nop56 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nop56
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nop56 is involved
PathwayEvidenceSource
Association of TriC/CCT with target proteins during biosynthesis IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here