Gene description for Brms1
Gene name breast cancer metastasis-suppressor 1
Gene symbol Brms1
Other names/aliases AV003220
AW554636
Species Mus musculus
 Database cross references - Brms1
ExoCarta ExoCarta_107392
Vesiclepedia VP_107392
Entrez Gene 107392
UniProt Q99N20  
 Brms1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Brms1
Molecular Function
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IBA
    NF-kappaB binding GO:0051059 IEA
    NF-kappaB binding GO:0051059 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 NAS
    apoptotic process GO:0006915 IEA
    negative regulation of cell migration GO:0030336 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 NAS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISS
    regulation of apoptotic process GO:0042981 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of protein deacetylation GO:0090312 ISO
    positive regulation of protein deacetylation GO:0090312 ISS
    negative regulation of stem cell population maintenance GO:1902455 NAS
    positive regulation of stem cell population maintenance GO:1902459 NAS
    positive regulation of anoikis GO:2000210 ISO
    positive regulation of anoikis GO:2000210 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleus GO:0005634 NAS
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    Sin3-type complex GO:0070822 IBA
    Sin3-type complex GO:0070822 NAS
 Experiment description of studies that identified Brms1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Brms1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nanog  
Affinity Capture-MS Mus musculus
2 Hdac1 433759
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Brms1 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HDACs deacetylate histones IEA Reactome





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