Gene description for Brms1
Gene name breast cancer metastasis-suppressor 1
Gene symbol Brms1
Other names/aliases AV003220
AW554636
Species Mus musculus
 Database cross references - Brms1
ExoCarta ExoCarta_107392
Entrez Gene 107392
UniProt Q99N20  
 Brms1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Brms1
Molecular Function
    histone deacetylase activity GO:0004407 IBA
    NF-kappaB binding GO:0051059 ISO
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IBA
Biological Process
    positive regulation of anoikis GO:2000210 ISO
    apoptotic process GO:0006915 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of protein deacetylation GO:0090312 ISO
    histone deacetylation GO:0016575 IBA
    cellular process GO:0009987 IDA
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    Sin3-type complex GO:0070822 IBA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Brms1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Brms1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Brms1 is involved
PathwayEvidenceSource
HDACs deacetylate histones IEA Reactome





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