Gene description for Yy1
Gene name YY1 transcription factor
Gene symbol Yy1
Other names/aliases AW488674
NF-E1
Species Mus musculus
 Database cross references - Yy1
ExoCarta ExoCarta_22632
Vesiclepedia VP_22632
Entrez Gene 22632
UniProt Q00899  
 Yy1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Yy1
Molecular Function
    four-way junction DNA binding GO:0000400 IEA
    four-way junction DNA binding GO:0000400 ISO
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISO
    cis-regulatory region sequence-specific DNA binding GO:0000987 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 ISO
    chromatin binding GO:0003682 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    RNA binding GO:0003723 ISO
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific DNA binding GO:0043565 ISO
    SMAD binding GO:0046332 IEA
    SMAD binding GO:0046332 ISO
    metal ion binding GO:0046872 IEA
    DNA-binding transcription factor binding GO:0140297 IEA
    DNA-binding transcription factor binding GO:0140297 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    telomere maintenance GO:0000723 IMP
    double-strand break repair via homologous recombination GO:0000724 IEA
    double-strand break repair via homologous recombination GO:0000724 ISO
    regulation of DNA replication GO:0006275 ISO
    regulation of DNA repair GO:0006282 IDA
    chromatin remodeling GO:0006338 ISO
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    RNA localization GO:0006403 IMP
    DNA damage response GO:0006974 IMP
    DNA damage response GO:0006974 ISO
    spermatogenesis GO:0007283 IMP
    anterior/posterior pattern specification GO:0009952 IGI
    anterior/posterior pattern specification GO:0009952 IMP
    response to UV-C GO:0010225 IMP
    response to UV-C GO:0010225 ISO
    gene expression GO:0010467 IDA
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of gene expression GO:0010629 ISO
    hemopoiesis GO:0030097 IMP
    B cell differentiation GO:0030183 IMP
    negative regulation of interferon-beta production GO:0032688 IEA
    negative regulation of interferon-beta production GO:0032688 ISO
    regulation of chromosome organization GO:0033044 ISO
    cellular response to UV GO:0034644 IEA
    cellular response to UV GO:0034644 ISO
    response to prostaglandin F GO:0034696 IEA
    positive regulation of DNA repair GO:0045739 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    regulation of embryonic development GO:0045995 IMP
    camera-type eye morphogenesis GO:0048593 IGI
    chromosome organization GO:0051276 IMP
    regulation of cell cycle GO:0051726 ISO
    regulation of DNA strand elongation GO:0060382 ISO
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 IEA
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 ISO
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to interleukin-1 GO:0071347 ISO
    immunoglobulin heavy chain V-D-J recombination GO:0071707 IMP
    negative regulation of miRNA transcription GO:1902894 IDA
    positive regulation of telomere maintenance in response to DNA damage GO:1904507 IMP
Subcellular Localization
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IBA
    transcription regulator complex GO:0005667 IDA
    transcription regulator complex GO:0005667 ISO
    chromatin silencing complex GO:0005677 IDA
    cytoplasm GO:0005737 IEA
    nuclear matrix GO:0016363 IEA
    nuclear matrix GO:0016363 ISO
    Ino80 complex GO:0031011 ISO
    PcG protein complex GO:0031519 IBA
    PcG protein complex GO:0031519 IDA
 Experiment description of studies that identified Yy1 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Yy1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sin3a  
Affinity Capture-Western Mus musculus
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Mtor  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
4 Elf5  
Affinity Capture-MS Mus musculus
5 Fos  
Affinity Capture-Western Mus musculus
6 Ctcf 13018
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
7 Gon4l 76022
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
8 Foxp3  
Affinity Capture-MS Mus musculus
9 Hdac1 433759
Affinity Capture-Western Mus musculus
10 Zfp42  
Affinity Capture-MS Mus musculus
11 Phc3  
Affinity Capture-Western Mus musculus
12 Smarca4  
Affinity Capture-RNA Mus musculus
13 Ppargc1a  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
14 Sp3  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
15 Ep300  
Affinity Capture-Western Mus musculus
16 Hdac2  
Affinity Capture-Western Mus musculus
17 Rptor  
Affinity Capture-Western Mus musculus
18 Usp8  
Affinity Capture-Western Mus musculus
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