Gene description for Yy1
Gene name YY1 transcription factor
Gene symbol Yy1
Other names/aliases AW488674
NF-E1
Species Mus musculus
 Database cross references - Yy1
ExoCarta ExoCarta_22632
Entrez Gene 22632
UniProt Q00899  
 Yy1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Yy1
Molecular Function
    sequence-specific DNA binding GO:0043565 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    metal ion binding GO:0046872 IEA
    SMAD binding GO:0046332 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    nucleic acid binding GO:0003676 IEA
    four-way junction DNA binding GO:0000400 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
    enhancer sequence-specific DNA binding GO:0001158 ISO
    RNA binding GO:0003723 ISO
    histone deacetylase binding GO:0042826 ISO
    DNA binding GO:0003677 ISO
    protein binding GO:0005515 IPI
Biological Process
    cellular response to UV GO:0034644 ISO
    cellular response to DNA damage stimulus GO:0006974 ISO
    DNA repair GO:0006281 IEA
    cell differentiation GO:0030154 IEA
    regulation of transcription, DNA-templated GO:0006355 ISO
    camera-type eye morphogenesis GO:0048593 IGI
    DNA recombination GO:0006310 IEA
    spermatogenesis GO:0007283 IMP
    cellular response to interleukin-1 GO:0071347 ISO
    double-strand break repair via homologous recombination GO:0000724 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    anterior/posterior pattern specification GO:0009952 IMP
    transcription, DNA-templated GO:0006351 IEA
    RNA localization GO:0006403 IMP
    chromosome organization GO:0051276 IMP
    positive regulation of gene expression GO:0010628 IDA
    response to UV-C GO:0010225 ISO
    negative regulation of gene expression GO:0010629 ISO
    transcription from RNA polymerase II promoter GO:0006366 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
Subcellular Localization
    transcription factor complex GO:0005667 ISO
    Ino80 complex GO:0031011 ISO
    PcG protein complex GO:0031519 IDA
    nuclear matrix GO:0016363 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Yy1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Yy1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Yy1 is involved
No pathways found





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