Gene description for Ctcf
Gene name CCCTC-binding factor
Gene symbol Ctcf
Other names/aliases AW108038
Species Mus musculus
 Database cross references - Ctcf
ExoCarta ExoCarta_13018
Entrez Gene 13018
UniProt Q61164  
 Ctcf identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ctcf
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IDA
    chromatin insulator sequence binding GO:0043035 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IDA
    nucleic acid binding GO:0003676 IEA
    metal ion binding GO:0046872 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 ISO
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    transcription from RNA polymerase II promoter GO:0006366 IDA
    chromosome segregation GO:0007059 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    chromatin modification GO:0016568 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    regulation of histone methylation GO:0031060 IMP
    regulation of transcription, DNA-templated GO:0006355 IDA
    negative regulation of gene expression GO:0010629 IMP
    nucleosome positioning GO:0016584 ISO
    regulation of molecular function, epigenetic GO:0040030 ISO
    regulation of gene expression, epigenetic GO:0040029 ISO
    dosage compensation by inactivation of X chromosome GO:0009048 TAS
    regulation of gene expression by genetic imprinting GO:0006349 IMP
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    positive regulation of gene expression GO:0010628 ISO
    transcription, DNA-templated GO:0006351 IEA
    maintenance of DNA methylation GO:0010216 IMP
    regulation of histone acetylation GO:0035065 IMP
    DNA methylation GO:0006306 IMP
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    condensed chromosome GO:0000793 ISO
    chromosome, centromeric region GO:0000775 ISO
    nucleolus GO:0005730 ISO
    chromosome GO:0005694 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Ctcf in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ctcf
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ctcf is involved
No pathways found





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