Gene description for Sp1
Gene name trans-acting transcription factor 1
Gene symbol Sp1
Other names/aliases 1110003E12Rik
AA450830
AI845540
Sp1-1
Species Mus musculus
 Database cross references - Sp1
ExoCarta ExoCarta_20683
Entrez Gene 20683
UniProt O89090  
 Sp1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sp1
Molecular Function
    histone acetyltransferase binding GO:0035035 ISO
    enhancer binding GO:0035326 IDA
    core promoter sequence-specific DNA binding GO:0001046 IDA
    metal ion binding GO:0046872 IEA
    bHLH transcription factor binding GO:0043425 IPI
    sequence-specific DNA binding GO:0043565 ISO
    transcription factor binding GO:0008134 ISO
    protein binding GO:0005515 IPI
    double-stranded DNA binding GO:0003690 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    protein C-terminus binding GO:0008022 ISO
    protein homodimerization activity GO:0042803 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    nucleic acid binding GO:0003676 IEA
    histone deacetylase binding GO:0042826 ISO
    HMG box domain binding GO:0071837 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    core promoter proximal region sequence-specific DNA binding GO:0000987 IDA
    DNA binding GO:0003677 ISS
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IDA
    RNA polymerase II repressing transcription factor binding GO:0001103 IPI
    transcription regulatory region DNA binding GO:0044212 ISO
Biological Process
    embryonic camera-type eye morphogenesis GO:0048596 IGI
    ossification GO:0001503 IGI
    positive regulation by host of viral transcription GO:0043923 ISO
    transcription, DNA-templated GO:0006351 IEA
    liver development GO:0001889 IGI
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    embryonic process involved in female pregnancy GO:0060136 IGI
    rhythmic process GO:0048511 IEA
    lung development GO:0030324 IGI
    embryonic placenta development GO:0001892 IGI
    megakaryocyte differentiation GO:0030219 IGI
    regulation of transcription, DNA-templated GO:0006355 ISO
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISO
    in utero embryonic development GO:0001701 IGI
    transcription from RNA polymerase II promoter GO:0006366 IDA
    definitive hemopoiesis GO:0060216 IGI
    embryonic skeletal system development GO:0048706 IGI
    trophectodermal cell differentiation GO:0001829 IGI
    enucleate erythrocyte differentiation GO:0043353 IGI
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nuclear chromatin GO:0000790 ISO
    protein-DNA complex GO:0032993 ISO
 Experiment description of studies that identified Sp1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 E2f1  
Reconstituted Complex Mus musculus
View the network image/svg+xml



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