Gene description for Cd36
Gene name CD36 antigen
Gene symbol Cd36
Other names/aliases FAT
GPIV
Scarb3
Species Mus musculus
 Database cross references - Cd36
ExoCarta ExoCarta_12491
Entrez Gene 12491
UniProt Q08857  
 Cd36 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Cd36
Molecular Function
    oleic acid binding GO:0070538 ISO
    transforming growth factor beta binding GO:0050431 ISO
    high-density lipoprotein particle binding GO:0008035 IDA
    lipoprotein particle binding GO:0071813 ISO
    low-density lipoprotein particle binding GO:0030169 ISO
    lipoteichoic acid receptor activity GO:0070892 IMP
    low-density lipoprotein receptor activity GO:0005041 ISO
    lipid binding GO:0008289 ISS
    thrombospondin receptor activity GO:0070053 ISO
    protein binding GO:0005515 IPI
Biological Process
    pattern recognition receptor signaling pathway GO:0002221 IMP
    positive regulation of macrophage cytokine production GO:0060907 IMP
    triglyceride metabolic process GO:0006641 ISO
    response to mechanical stimulus GO:0009612 ISO
    long-chain fatty acid import GO:0044539 ISO
    negative regulation of systemic arterial blood pressure GO:0003085 ISO
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    cGMP-mediated signaling GO:0019934 ISO
    positive regulation of cytokine secretion GO:0050715 ISO
    positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO
    fatty acid metabolic process GO:0006631 ISO
    long-chain fatty acid transport GO:0015909 ISO
    signal transduction GO:0007165 ISO
    cellular response to bacterial lipopeptide GO:0071221 IMP
    positive regulation of interleukin-12 production GO:0032735 IMP
    plasma lipoprotein particle clearance GO:0034381 IMP
    fatty acid oxidation GO:0019395 ISO
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    regulation of removal of superoxide radicals GO:2000121 IMP
    negative regulation of gene expression GO:0010629 IMP
    long-chain fatty acid metabolic process GO:0001676 ISO
    cellular response to hydroperoxide GO:0071447 IMP
    positive regulation of reactive oxygen species metabolic process GO:2000379 IMP
    cellular response to lipopolysaccharide GO:0071222 IMP
    lipid storage GO:0019915 ISO
    cell surface receptor signaling pathway GO:0007166 IDA
    positive regulation of cholesterol storage GO:0010886 IMP
    lipoprotein transport GO:0042953 ISO
    cell adhesion GO:0007155 IEA
    negative regulation of angiogenesis GO:0016525 ISO
    positive regulation of MAPK cascade GO:0043410 IMP
    negative regulation of transcription factor import into nucleus GO:0042992 IMP
    cellular response to lipoteichoic acid GO:0071223 IMP
    defense response to Gram-positive bacterium GO:0050830 IMP
    positive regulation of phagocytosis, engulfment GO:0060100 IMP
    transport GO:0006810 IEA
    plasma membrane long-chain fatty acid transport GO:0015911 ISO
    low-density lipoprotein particle clearance GO:0034383 ISO
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619 IC
    cholesterol transport GO:0030301 IMP
    receptor-mediated endocytosis GO:0006898 IMP
    low-density lipoprotein particle mediated signaling GO:0055096 IDA
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    positive regulation of blood microparticle formation GO:2000334 IMP
    positive regulation of blood coagulation GO:0030194 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    negative regulation of growth of symbiont in host GO:0044130 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    apoptotic cell clearance GO:0043277 IMP
    fatty acid transport GO:0015908 ISO
    nitric oxide mediated signal transduction GO:0007263 ISO
    phagocytosis, recognition GO:0006910 IDA
Subcellular Localization
    sarcolemma GO:0042383 ISO
    mitochondrion GO:0005739 ISO
    caveola GO:0005901 ISO
    plasma membrane GO:0005886 ISO
    protein complex GO:0043234 ISO
    cell surface GO:0009986 ISS
    apical part of cell GO:0045177 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    membrane raft GO:0045121 IDA
    extracellular space GO:0005615 ISO
    intracellular GO:0005622 ISO
    integral component of membrane GO:0016021 IEA
    external side of plasma membrane GO:0009897 IDA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 IEA
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Cd36 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cd36
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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