Gene description for Uchl1
Gene name ubiquitin carboxy-terminal hydrolase L1
Gene symbol Uchl1
Other names/aliases AW822034
PGP 9.5
Species Mus musculus
 Database cross references - Uchl1
ExoCarta ExoCarta_22223
Entrez Gene 22223
UniProt Q9R0P9  
 Uchl1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Uchl1
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IDA
    ligase activity GO:0016874 IEA
    peptidase activity GO:0008233 IEA
    alpha-2A adrenergic receptor binding GO:0031694 ISO
    cysteine-type peptidase activity GO:0008234 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    cysteine-type endopeptidase activity GO:0004197 ISO
    omega peptidase activity GO:0008242 ISO
    hydrolase activity GO:0016787 IEA
    ubiquitin binding GO:0043130 ISO
Biological Process
    proteolysis GO:0006508 IDA
    muscle fiber development GO:0048747 IGI
    eating behavior GO:0042755 IGI
    axon transport of mitochondrion GO:0019896 IMP
    negative regulation of MAP kinase activity GO:0043407 ISO
    adult walking behavior GO:0007628 IMP
    cell proliferation GO:0008283 IMP
    sensory perception of pain GO:0019233 ISO
    axon target recognition GO:0007412 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    neuromuscular process GO:0050905 IMP
    protein deubiquitination GO:0016579 ISO
    response to ischemia GO:0002931 IMP
    axonogenesis GO:0007409 IMP
Subcellular Localization
    neuron projection terminus GO:0044306 IDA
    neuronal cell body GO:0043025 IDA
    myelin sheath GO:0043209 IDA
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 ISO
    intracellular GO:0005622 IMP
    nucleoplasm GO:0005654 ISO
    axon GO:0030424 IDA
    cell GO:0005623 IMP
    cytosol GO:0005829 IDA
    endoplasmic reticulum GO:0005783 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Uchl1 in exosomes
Experiment ID 188
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uchl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uchl1 is involved
No pathways found

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