Gene description for Nono
Gene name non-POU-domain-containing, octamer binding protein
Gene symbol Nono
Other names/aliases AA407051
Species Mus musculus
 Database cross references - Nono
ExoCarta ExoCarta_53610
Entrez Gene 53610
UniProt Q99K48  
 Nono identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Pancreatic cells 19351151    
 Gene ontology annotations for Nono
Molecular Function
    core promoter binding GO:0001047 IDA
    RNA binding GO:0003723 IEA
    DNA binding GO:0003677 IEA
    poly(A) RNA binding GO:0044822 ISO
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    nucleic acid binding GO:0003676 IEA
Biological Process
    rhythmic process GO:0048511 IEA
    circadian rhythm GO:0007623 ISO
    DNA recombination GO:0006310 IEA
    RNA splicing GO:0008380 IEA
    DNA repair GO:0006281 IEA
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISO
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of circadian rhythm GO:0042752 IMP
    mRNA processing GO:0006397 IEA
    cellular response to DNA damage stimulus GO:0006974 IEA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
    membrane GO:0016020 ISO
    nuclear matrix GO:0016363 ISO
    paraspeckles GO:0042382 ISO
 Experiment description of studies that identified Nono in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Experiment ID 188
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nono
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CPNE1 8904
Reconstituted Complex Homo sapiens
2 CPNE4 131034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Nono is involved
No pathways found

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