Gene description for IRS2
Gene name	insulin receptor substrate 2
Gene symbol	IRS2
Other names/aliases	IRS-2
Species	Homo sapiens
Database cross references - IRS2
ExoCarta	ExoCarta_8660
Vesiclepedia	VP_8660
Entrez Gene	8660
HGNC	6126
MIM	600797
UniProt	Q9Y4H2
IRS2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Neuroblastoma cells	25944692

Gene ontology annotations for IRS2

Molecular Function     protein domain specific binding GO:0019904 IEA     protein binding GO:0005515 IPI     phosphatidylinositol 3-kinase binding GO:0043548 IBA     14-3-3 protein binding GO:0071889 IEA     signal transducer activity GO:0004871 IEA     protein kinase binding GO:0019901 IEA     insulin receptor binding GO:0005158 IBA     protein phosphatase binding GO:0019903 IEA Biological Process     innate immune response GO:0045087 TAS     brain development GO:0007420 IEA     positive regulation of glucose import GO:0046326 IMP     response to glucose GO:0009749 ISS     mammary gland development GO:0030879 IEA     positive regulation of cell migration GO:0030335 IEA     signal transduction GO:0007165 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     negative regulation of B cell apoptotic process GO:0002903 ISS     insulin receptor signaling pathway GO:0008286 TAS     positive regulation of insulin secretion GO:0032024 ISS     lipid homeostasis GO:0055088 TAS     positive regulation of B cell proliferation GO:0030890 ISS     glucose metabolic process GO:0006006 TAS     cell proliferation GO:0008283 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     cellular response to glucose stimulus GO:0071333 IEA     positive regulation of glucose metabolic process GO:0010907 IMP     cellular response to insulin stimulus GO:0032869 IMP     negative regulation of kinase activity GO:0033673 ISS     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     positive regulation of cell proliferation GO:0008284 NAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     negative regulation of plasma membrane long-chain fatty acid transport GO:0010748 IMP     regulation of lipid metabolic process GO:0019216 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of fatty acid beta-oxidation GO:0032000 IMP     positive regulation of glycogen biosynthetic process GO:0045725 NAS Subcellular Localization     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS