Gene description for TYRO3
Gene name TYRO3 protein tyrosine kinase
Gene symbol TYRO3
Other names/aliases BYK
Dtk
Etk-2
RSE
Rek
Sky
Tif
Species Homo sapiens
 Database cross references - TYRO3
ExoCarta ExoCarta_7301
Vesiclepedia VP_7301
Entrez Gene 7301
HGNC 12446
MIM 600341
UniProt Q06418  
 TYRO3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TYRO3
Molecular Function
    phosphatidylinositol 3-kinase binding GO:0043548 IPI
    protein tyrosine kinase activity GO:0004713 IDA
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 NAS
    ATP binding GO:0005524 IEA
    receptor signaling protein tyrosine kinase activity GO:0004716 NAS
Biological Process
    spermatogenesis GO:0007283 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 NAS
    negative regulation of innate immune response GO:0045824 ISS
    negative regulation of inflammatory response GO:0050728 ISS
    platelet aggregation GO:0070527 ISS
    ovulation cycle GO:0042698 ISS
    vagina development GO:0060068 IEA
    forebrain cell migration GO:0021885 ISS
    signal transduction GO:0007165 NAS
    protein kinase B signaling GO:0043491 ISS
    negative regulation of lymphocyte activation GO:0051250 IEA
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    signal transduction by protein phosphorylation GO:0023014 NAS
    cell adhesion GO:0007155 NAS
    negative regulation of toll-like receptor signaling pathway GO:0034122 ISS
    apoptotic cell clearance GO:0043277 ISS
    phosphatidylinositol 3-kinase signaling GO:0014065 NAS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    platelet activation GO:0030168 ISS
    natural killer cell differentiation GO:0001779 IEA
    protein autophosphorylation GO:0046777 IDA
    neuron cellular homeostasis GO:0070050 ISS
    secretion by cell GO:0032940 ISS
Subcellular Localization
    integral component of plasma membrane GO:0005887 NAS
    endoplasmic reticulum membrane GO:0005789 ISS
    nuclear envelope GO:0005635 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified TYRO3 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TYRO3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GAS6 2621
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 PIK3R1 5295
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 PROS1 5627
Invivo Homo sapiens
4 SRC 6714
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TYRO3 is involved
No pathways found





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