Gene description for DUSP26
Gene name dual specificity phosphatase 26 (putative)
Gene symbol DUSP26
Other names/aliases DSP-4
DUSP24
LDP-4
MKP-8
MKP8
NATA1
NEAP
SKRP3
Species Homo sapiens
 Database cross references - DUSP26
ExoCarta ExoCarta_78986
Entrez Gene 78986
HGNC 28161
UniProt Q9BV47  
 DUSP26 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for DUSP26
Molecular Function
    phosphoserine phosphatase activity GO:0004647 IMP
    RNA polymerase II activating transcription factor binding GO:0001102 IPI
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    phosphoprotein phosphatase activity GO:0004721 IDA
    protein binding GO:0005515 IPI
    p53 binding GO:0002039 IPI
    protein tyrosine phosphatase activity GO:0004725 IMP
Biological Process
    positive regulation of peptidyl-serine dephosphorylation GO:1902310 IDA
    protein dephosphorylation GO:0006470 IDA
    peptidyl-tyrosine dephosphorylation GO:0035335 IMP
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    positive regulation of cell adhesion GO:0045785 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified DUSP26 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DUSP26
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DUSP26 is involved
No pathways found





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