Gene description for DUSP26
Gene name dual specificity phosphatase 26 (putative)
Gene symbol DUSP26
Other names/aliases DSP-4
DUSP24
LDP-4
MKP-8
MKP8
NATA1
NEAP
SKRP3
Species Homo sapiens
 Database cross references - DUSP26
ExoCarta ExoCarta_78986
Vesiclepedia VP_78986
Entrez Gene 78986
HGNC 28161
UniProt Q9BV47  
 DUSP26 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for DUSP26
Molecular Function
    p53 binding GO:0002039 IPI
    phosphoprotein phosphatase activity GO:0004721 IDA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IDA
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IMP
    myosin phosphatase activity GO:0017018 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    MAP kinase phosphatase activity GO:0033549 IBA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 IDA
    negative regulation of MAPK cascade GO:0043409 IBA
    positive regulation of cell adhesion GO:0045785 IMP
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified DUSP26 in exosomes
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DUSP26
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
2 NEURL4  
Proximity Label-MS Homo sapiens
3 PTPRG 5793
Proximity Label-MS Homo sapiens
4 WDR45  
Affinity Capture-MS Homo sapiens
5 HSF4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 TRMT10C 54931
Affinity Capture-MS Homo sapiens
7 DOCK7 85440
Affinity Capture-MS Homo sapiens
8 GOLGA6L9  
Two-hybrid Homo sapiens
9 DUSP26 78986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 HSD17B10 3028
Affinity Capture-MS Homo sapiens
11 RET 5979
Two-hybrid Homo sapiens
12 IGF1R 3480
Two-hybrid Homo sapiens
13 DPP4 1803
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
14 KRT27 342574
Two-hybrid Homo sapiens
15 EPHA7 2045
Two-hybrid Homo sapiens
16 ABTB2 25841
Affinity Capture-MS Homo sapiens
17 GID8 54994
Affinity Capture-MS Homo sapiens
18 UBR5 51366
Affinity Capture-MS Homo sapiens
19 HERC2 8924
Proximity Label-MS Homo sapiens
20 EPHA2 1969
Two-hybrid Homo sapiens
21 XPNPEP1 7511
Affinity Capture-MS Homo sapiens
22 EIF5A 1984
Affinity Capture-MS Homo sapiens
23 CALCOCO2  
Two-hybrid Homo sapiens
24 ATG2B 55102
Affinity Capture-MS Homo sapiens
25 DUSP23 54935
Affinity Capture-MS Homo sapiens
26 MDM2  
Affinity Capture-Western Homo sapiens
27 ZNF99  
Affinity Capture-MS Homo sapiens
28 DCTPP1 79077
Affinity Capture-MS Homo sapiens
29 PTK7 5754
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DUSP26 is involved
No pathways found





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