Gene description for Dynlrb1
Gene name dynein light chain roadblock-type 1
Gene symbol Dynlrb1
Other names/aliases 2010012N15Rik
2010320M17Rik
9430076K19Rik
AV124457
DNLC2A
Dncl2a
km23-1
Species Mus musculus
 Database cross references - Dynlrb1
ExoCarta ExoCarta_67068
Entrez Gene 67068
UniProt P62627  
 Dynlrb1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Dynlrb1
Molecular Function
    identical protein binding GO:0042802 IPI
    motor activity GO:0003774 IEA
    protein binding GO:0005515 IPI
Biological Process
    transport GO:0006810 IEA
    visual behavior GO:0007632 ISO
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    microtubule GO:0005874 IEA
    centrosome GO:0005813 ISO
    dynein complex GO:0030286 IEA
    cytoplasmic dynein complex GO:0005868 IDA
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Dynlrb1 in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dynlrb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dynlrb1 is involved
PathwayEvidenceSource
Intraflagellar transport IEA Reactome





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