Gene description for Dynlrb1
Gene name dynein light chain roadblock-type 1
Gene symbol Dynlrb1
Other names/aliases 2010012N15Rik
2010320M17Rik
9430076K19Rik
AV124457
DNLC2A
Dncl2a
km23-1
Species Mus musculus
 Database cross references - Dynlrb1
ExoCarta ExoCarta_67068
Vesiclepedia VP_67068
Entrez Gene 67068
UniProt P62627  
 Dynlrb1 identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Dynlrb1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    dynein intermediate chain binding GO:0045505 IBA
Biological Process
    microtubule-based movement GO:0007018 IBA
    microtubule-based movement GO:0007018 IEA
    visual behavior GO:0007632 ISO
    visual behavior GO:0007632 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    centrosome GO:0005813 IBA
    centrosome GO:0005813 ISO
    cytoplasmic dynein complex GO:0005868 IBA
    cytoplasmic dynein complex GO:0005868 IDA
    microtubule GO:0005874 IEA
    dynein complex GO:0030286 ISO
 Experiment description of studies that identified Dynlrb1 in sEVs
1
Experiment ID 264
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dynlrb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCTN1 1639
Affinity Capture-MS Homo sapiens
2 DYNC1I2 1781
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
3 CCDC82  
Affinity Capture-MS Homo sapiens
4 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
5 ACTR1A 10121
Affinity Capture-MS Homo sapiens
6 WDR60 55112
Affinity Capture-MS Homo sapiens
7 DYNC1I1  
Two-hybrid Homo sapiens
8 UBR2 23304
Affinity Capture-MS Homo sapiens
9 WDR34 89891
Affinity Capture-MS Homo sapiens
10 DCTN2 10540
Affinity Capture-MS Homo sapiens
11 DYNC1LI1 51143
Affinity Capture-MS Homo sapiens
12 DYNC1LI2 1783
Affinity Capture-MS Homo sapiens
13 RANGAP1 5905
Affinity Capture-MS Homo sapiens
14 LUC7L 55692
Affinity Capture-MS Homo sapiens
15 YTHDF1 54915
Two-hybrid Homo sapiens
16 DYNLT3 6990
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Dynlrb1 is involved
PathwayEvidenceSource
Cilium Assembly IEA Reactome
Intraflagellar transport IEA Reactome
Organelle biogenesis and maintenance IEA Reactome





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