Gene description for ADCK4
Gene name aarF domain containing kinase 4
Gene symbol ADCK4
Other names/aliases NPHS9
Species Homo sapiens
 Database cross references - ADCK4
ExoCarta ExoCarta_79934
Vesiclepedia VP_79934
Entrez Gene 79934
HGNC 19041
MIM 615567
UniProt Q96D53  
 ADCK4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ADCK4
Molecular Function
    protein kinase activity GO:0004672 IDA
    ATP binding GO:0005524 IEA
    lipid binding GO:0008289 ISS
    ATP hydrolysis activity GO:0016887 ISS
Biological Process
    protein phosphorylation GO:0006468 IDA
    ubiquinone biosynthetic process GO:0006744 IBA
    ubiquinone biosynthetic process GO:0006744 IMP
    cerebellar Purkinje cell layer morphogenesis GO:0021692 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IEA
    mitochondrial membrane GO:0031966 IEA
 Experiment description of studies that identified ADCK4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADCK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif19a  
Affinity Capture-MS Mus musculus
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 KLK15  
Affinity Capture-MS Homo sapiens
5 ADCK3  
Affinity Capture-MS Homo sapiens
6 HCST  
Affinity Capture-MS Homo sapiens
7 MTG2  
Proximity Label-MS Homo sapiens
8 SLC2A1 6513
Affinity Capture-MS Homo sapiens
9 FPR1  
Affinity Capture-MS Homo sapiens
10 FFAR1  
Affinity Capture-MS Homo sapiens
11 PMPCA 23203
Affinity Capture-MS Homo sapiens
12 COQ9  
Affinity Capture-MS Homo sapiens
13 CHCHD2  
Affinity Capture-MS Homo sapiens
14 YARS2  
Affinity Capture-MS Homo sapiens
15 COQ3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 GPR55  
Affinity Capture-MS Homo sapiens
17 ATP5O 539
Affinity Capture-MS Homo sapiens
18 P2RY10  
Affinity Capture-MS Homo sapiens
19 EXD2  
Proximity Label-MS Homo sapiens
20 ERAL1  
Affinity Capture-MS Homo sapiens
21 F2RL1  
Affinity Capture-MS Homo sapiens
22 MRPS7 51081
Affinity Capture-MS Homo sapiens
23 TIMM50 92609
Affinity Capture-MS Homo sapiens
24 PMPCB 9512
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ADCK4 79934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PTH1R  
Affinity Capture-MS Homo sapiens
27 GPR17 2840
Affinity Capture-MS Homo sapiens
28 STOML2 30968
Affinity Capture-MS Homo sapiens
29 KCNK1  
Affinity Capture-MS Homo sapiens
30 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ACSM5 54988
Affinity Capture-MS Homo sapiens
32 GCGR  
Affinity Capture-MS Homo sapiens
33 P2RY8  
Affinity Capture-MS Homo sapiens
34 AMACR 23600
Affinity Capture-MS Homo sapiens
35 OGT 8473
Reconstituted Complex Homo sapiens
36 GPR182  
Affinity Capture-MS Homo sapiens
37 POLDIP2 26073
Affinity Capture-MS Homo sapiens
38 MTRF1L  
Proximity Label-MS Homo sapiens
39 RASL10B  
Affinity Capture-MS Homo sapiens
40 P2RX4 5025
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 EFNA4  
Affinity Capture-MS Homo sapiens
43 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 AK4 205
Affinity Capture-MS Homo sapiens
45 PITRM1 10531
Affinity Capture-MS Homo sapiens
46 EGLN3  
Affinity Capture-MS Homo sapiens
47 DUOXA2  
Affinity Capture-MS Homo sapiens
48 NPTN 27020
Affinity Capture-MS Homo sapiens
49 ATP5H 10476
Affinity Capture-MS Homo sapiens
50 CMKLR1 1240
Affinity Capture-MS Homo sapiens
51 MGARP  
Affinity Capture-MS Homo sapiens
52 CUL3 8452
Affinity Capture-MS Homo sapiens
53 ATP5F1 515
Affinity Capture-MS Homo sapiens
54 FAHD1 81889
Affinity Capture-MS Homo sapiens
55 KLRG2 346689
Affinity Capture-MS Homo sapiens
56 AQP3  
Affinity Capture-MS Homo sapiens
57 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
58 Hoxa1  
Two-hybrid Mus musculus
59 CD27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 MTG1  
Proximity Label-MS Homo sapiens
61 ATP5E 514
Affinity Capture-MS Homo sapiens
62 GPR45  
Affinity Capture-MS Homo sapiens
63 CLPB 81570
Affinity Capture-MS Homo sapiens
64 QRSL1  
Affinity Capture-MS Homo sapiens
65 LPPR2  
Affinity Capture-MS Homo sapiens
66 MCUR1 63933
Proximity Label-MS Homo sapiens
67 MAGEA8  
Affinity Capture-MS Homo sapiens
68 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CLPP 8192
Proximity Label-MS Homo sapiens
70 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
71 VIPR1  
Affinity Capture-MS Homo sapiens
72 MRPS2 51116
Affinity Capture-MS Homo sapiens
73 COQ5  
Affinity Capture-MS Homo sapiens
74 COQ6 51004
Affinity Capture-MS Homo sapiens
75 MFSD4  
Affinity Capture-MS Homo sapiens
76 TNFSF14  
Affinity Capture-MS Homo sapiens
77 GOLPH3 64083
Affinity Capture-MS Homo sapiens
78 COQ7  
Affinity Capture-MS Homo sapiens
79 MYL10 93408
Affinity Capture-MS Homo sapiens
80 BRD1 23774
Affinity Capture-MS Homo sapiens
81 C1QBP 708
Affinity Capture-MS Homo sapiens
82 ATP5C1 509
Affinity Capture-MS Homo sapiens
83 SLC1A1 6505
Affinity Capture-MS Homo sapiens
84 TRIM43  
Affinity Capture-MS Homo sapiens
85 TIMM44 10469
Affinity Capture-MS Homo sapiens
86 SHC2 25759
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADCK4 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of cofactors TAS Reactome
Metabolism of vitamins and cofactors TAS Reactome
Ubiquinol biosynthesis TAS Reactome





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