Gene description for TOMM7
Gene name translocase of outer mitochondrial membrane 7 homolog (yeast)
Gene symbol TOMM7
Other names/aliases TOM7
Species Homo sapiens
 Database cross references - TOMM7
ExoCarta ExoCarta_54543
Vesiclepedia VP_54543
Entrez Gene 54543
HGNC 21648
MIM 607980
UniProt Q9P0U1  
 TOMM7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TOMM7
Molecular Function
    protein binding GO:0005515 IPI
    protein transmembrane transporter activity GO:0008320 TAS
Biological Process
    protein targeting to mitochondrion GO:0006626 TAS
    protein import into mitochondrial matrix GO:0030150 IEA
    regulation of protein stability GO:0031647 IMP
    protein insertion into mitochondrial outer membrane GO:0045040 NAS
    positive regulation of protein targeting to mitochondrion GO:1903955 IBA
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    positive regulation of type 2 mitophagy GO:1905091 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 NAS
    mitochondrial outer membrane GO:0005741 TAS
    mitochondrial outer membrane translocase complex GO:0005742 IBA
    mitochondrial outer membrane translocase complex GO:0005742 IDA
    mitochondrial outer membrane translocase complex GO:0005742 TAS
    TOM complex GO:0140596 NAS
 Experiment description of studies that identified TOMM7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TOMM7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOMM40 10452
Co-fractionation Homo sapiens
2 CISD1 55847
Co-fractionation Homo sapiens
3 UQCRFS1 7386
Co-fractionation Homo sapiens
4 TIMM50 92609
Co-fractionation Homo sapiens
5 ACAT1 38
Co-fractionation Homo sapiens
6 AMY2A 279
Affinity Capture-MS Homo sapiens
7 SFXN1 94081
Co-fractionation Homo sapiens
8 KIF20A 10112
Affinity Capture-MS Homo sapiens
9 LRRC59 55379
Cross-Linking-MS (XL-MS) Homo sapiens
10 FAM3C 10447
Co-fractionation Homo sapiens
11 COX15 1355
Co-fractionation Homo sapiens
12 NDUFB7 4713
Co-fractionation Homo sapiens
13 ERGIC1 57222
Co-fractionation Homo sapiens
14 SRSF3 6428
Co-fractionation Homo sapiens
15 TOMM40L  
Affinity Capture-MS Homo sapiens
16 TOMM22 56993
Co-fractionation Homo sapiens
17 TOMM70A 9868
Co-fractionation Homo sapiens
18 BAK1 578
Co-fractionation Homo sapiens
19 TOMM6  
Affinity Capture-MS Homo sapiens
20 SDHB 6390
Co-fractionation Homo sapiens
21 SFXN2  
Co-fractionation Homo sapiens
22 PRC1 9055
Affinity Capture-MS Homo sapiens
23 PEX5 5830
Two-hybrid Homo sapiens
24 TPP2 7174
Cross-Linking-MS (XL-MS) Homo sapiens
25 ACTR1A 10121
Cross-Linking-MS (XL-MS) Homo sapiens
26 MSN 4478
Cross-Linking-MS (XL-MS) Homo sapiens
27 TOMM5  
Cross-Linking-MS (XL-MS) Homo sapiens
28 TOMM20 9804
Co-fractionation Homo sapiens
View the network image/svg+xml



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