Gene description for DUSP6
Gene name	dual specificity phosphatase 6
Gene symbol	DUSP6
Other names/aliases	HH19 MKP3 PYST1
Species	Homo sapiens
Database cross references - DUSP6
ExoCarta	ExoCarta_1848
Vesiclepedia	VP_1848
Entrez Gene	1848
HGNC	3072
MIM	602748
UniProt	Q16828
DUSP6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for DUSP6

Molecular Function     protein tyrosine phosphatase activity GO:0004725 IEA     MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 IDA Biological Process     cell differentiation GO:0030154 IEA     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     response to nitrosative stress GO:0051409 IEP     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     dorsal/ventral pattern formation GO:0009953 IBA     peptidyl-tyrosine dephosphorylation GO:0035335 IDA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     positive regulation of apoptotic process GO:0043065 IDA     regulation of fibroblast growth factor receptor signaling pathway GO:0040036 IBA     negative regulation of ERK1 and ERK2 cascade GO:0070373 IMP     inactivation of MAPK activity GO:0000188 IDA     toll-like receptor signaling pathway GO:0002224 TAS     regulation of heart growth GO:0060420 IBA     toll-like receptor 5 signaling pathway GO:0034146 TAS     stress-activated MAPK cascade GO:0051403 TAS     regulation of endodermal cell fate specification GO:0042663 IBA     innate immune response GO:0045087 TAS     toll-like receptor 3 signaling pathway GO:0034138 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     response to drug GO:0042493 IEA     response to organic cyclic compound GO:0014070 IEA     toll-like receptor 4 signaling pathway GO:0034142 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS Subcellular Localization     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 IEA     cytoplasm GO:0005737 IDA