Gene description for DUSP6
Gene name	dual specificity phosphatase 6
Gene symbol	DUSP6
Other names/aliases	HH19 MKP3 PYST1
Species	Homo sapiens
Database cross references - DUSP6
ExoCarta	ExoCarta_1848
Vesiclepedia	VP_1848
Entrez Gene	1848
HGNC	3072
MIM	602748
UniProt	Q16828
DUSP6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for DUSP6

Molecular Function     protein tyrosine phosphatase activity GO:0004725 TAS     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA     protein binding GO:0005515 IPI     protein tyrosine/serine/threonine phosphatase activity GO:0008138 TAS     protein tyrosine/threonine phosphatase activity GO:0008330 IBA     MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 IBA     MAP kinase tyrosine/serine/threonine phosphatase activity GO:0017017 IDA     myosin phosphatase activity GO:0017018 IEA     protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA     calmodulin-dependent protein phosphatase activity GO:0033192 IEA     MAP kinase tyrosine phosphatase activity GO:0033550 IBA     histone H2AXS140 phosphatase activity GO:0140791 IEA     histone H2AXY142 phosphatase activity GO:0140793 IEA     RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA     RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA     RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA     RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA     RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA     MAP kinase serine/threonine phosphatase activity GO:1990439 IEA Biological Process     MAPK cascade GO:0000165 TAS     chromatin remodeling GO:0006338 IEA     regulation of transcription by RNA polymerase II GO:0006357 IEA     signal transduction GO:0007165 IBA     response to xenobiotic stimulus GO:0009410 IEA     response to organic cyclic compound GO:0014070 IEA     cell differentiation GO:0030154 IEA     peptidyl-tyrosine dephosphorylation GO:0035335 IDA     positive regulation of apoptotic process GO:0043065 IBA     positive regulation of apoptotic process GO:0043065 IDA     negative regulation of MAPK cascade GO:0043409 IDA     response to nitrosative stress GO:0051409 IEP     regulation of heart growth GO:0060420 IBA     ERK1 and ERK2 cascade GO:0070371 TAS     negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA     negative regulation of ERK1 and ERK2 cascade GO:0070373 IMP     response to growth factor GO:0070848 IEA Subcellular Localization     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS