Gene description for Mapk8
Gene name	mitogen-activated protein kinase 8
Gene symbol	Mapk8
Other names/aliases	JNK
Species	Rattus norvegicus
Database cross references - Mapk8
ExoCarta	ExoCarta_116554
Vesiclepedia	VP_116554
Entrez Gene	116554
UniProt	P49185
Mapk8 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Mapk8

Molecular Function     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 ISO     JUN kinase activity GO:0004705 IBA     JUN kinase activity GO:0004705 IDA     JUN kinase activity GO:0004705 IEA     JUN kinase activity GO:0004705 ISO     JUN kinase activity GO:0004705 ISS     JUN kinase activity GO:0004705 TAS     protein serine/threonine/tyrosine kinase activity GO:0004712 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     kinase activity GO:0016301 ISO     kinesin binding GO:0019894 IPI     enzyme binding GO:0019899 ISO     protein phosphatase binding GO:0019903 IEA     protein phosphatase binding GO:0019903 ISO     histone deacetylase regulator activity GO:0035033 IEA     histone deacetylase regulator activity GO:0035033 ISO     histone deacetylase binding GO:0042826 IEA     histone deacetylase binding GO:0042826 ISO     protein serine kinase activity GO:0106310 IEA     protein serine/threonine kinase binding GO:0120283 IEA     protein serine/threonine kinase binding GO:0120283 ISO Biological Process     ossification GO:0001503 ISO     neuron migration GO:0001764 ISO     positive regulation of neuroblast proliferation GO:0002052 IMP     regulation of DNA-templated transcription GO:0006355 IDA     protein phosphorylation GO:0006468 ISO     protein phosphorylation GO:0006468 ISO     response to oxidative stress GO:0006979 ISO     integrin-mediated signaling pathway GO:0007229 ISO     JNK cascade GO:0007254 IBA     JNK cascade GO:0007254 IEA     JNK cascade GO:0007254 ISO     JNK cascade GO:0007254 ISS     JUN phosphorylation GO:0007258 ISO     JUN phosphorylation GO:0007258 ISO     response to UV GO:0009411 IEA     response to UV GO:0009411 ISO     response to mechanical stimulus GO:0009612 IBA     regulation of gene expression GO:0010468 ISO     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     positive regulation of cardiac muscle cell apoptotic process GO:0010666 IMP     peptidyl-serine phosphorylation GO:0018105 ISO     peptidyl-serine phosphorylation GO:0018105 ISO     peptidyl-serine phosphorylation GO:0018105 ISS     peptidyl-threonine phosphorylation GO:0018107 ISO     peptidyl-threonine phosphorylation GO:0018107 ISO     positive regulation of cell migration GO:0030335 IDA     positive regulation of microtubule polymerization GO:0031116 IMP     neuron projection development GO:0031175 IMP     positive regulation of cyclase activity GO:0031281 ISO     positive regulation of protein ubiquitination GO:0031398 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     regulation of protein localization GO:0032880 IEA     regulation of protein localization GO:0032880 ISO     cellular response to amino acid starvation GO:0034198 IEA     cellular response to amino acid starvation GO:0034198 ISO     glial cell apoptotic process GO:0034349 IEP     positive regulation of glial cell apoptotic process GO:0034352 IMP     cellular response to oxidative stress GO:0034599 ISO     cellular response to reactive oxygen species GO:0034614 IEA     cellular response to reactive oxygen species GO:0034614 ISO     response to hydrogen peroxide GO:0042542 IDA     regulation of circadian rhythm GO:0042752 ISO     regulation of circadian rhythm GO:0042752 ISS     positive regulation of apoptotic process GO:0043065 IBA     positive regulation of apoptotic process GO:0043065 IEP     negative regulation of apoptotic process GO:0043066 IDA     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of neuron apoptotic process GO:0043525 IMP     regulation of neuron differentiation GO:0045664 IMP     positive regulation of DNA replication GO:0045740 IMP     regulation of centrosome cycle GO:0046605 IMP     response to cadmium ion GO:0046686 ISO     rhythmic process GO:0048511 IEA     response to steroid hormone GO:0048545 IEP     neuron development GO:0048666 IEP     dendrite morphogenesis GO:0048813 ISO     modulation of chemical synaptic transmission GO:0050804 ISO     positive regulation of protein metabolic process GO:0051247 IEA     positive regulation of protein metabolic process GO:0051247 ISO     stress-activated MAPK cascade GO:0051403 IEA     stress-activated MAPK cascade GO:0051403 ISO     SMAD protein signal transduction GO:0060395 IMP     protein localization to tricellular tight junction GO:0061833 ISO     cellular response to hydrogen peroxide GO:0070301 ISO     cellular response to lipopolysaccharide GO:0071222 IEA     cellular response to lipopolysaccharide GO:0071222 ISO     cellular response to mechanical stimulus GO:0071260 IEA     cellular response to mechanical stimulus GO:0071260 ISO     cellular response to interleukin-1 GO:0071347 IEP     cellular response to nitric oxide GO:0071732 ISO     positive regulation of podosome assembly GO:0071803 ISO     cellular response to oxygen-glucose deprivation GO:0090650 IEP     cellular response to oxygen-glucose deprivation GO:0090650 IMP     energy homeostasis GO:0097009 ISO     type B pancreatic cell apoptotic process GO:0097050 IMP     neuronal stem cell population maintenance GO:0097150 IGI     neuronal stem cell population maintenance GO:0097150 IMP     apoptotic signaling pathway GO:0097190 ISO     programmed necrotic cell death GO:0097300 ISO     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IEA     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISO     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISS     cellular response to amyloid-beta GO:1904646 IEP     regulation of dense core granule transport GO:1904809 IDA     positive regulation of determination of dorsal identity GO:2000017 ISO     positive regulation of neuron migration GO:2001224 IMP     positive regulation of apoptotic signaling pathway GO:2001235 ISO Subcellular Localization     podosome GO:0002102 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 ISO     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     axon GO:0030424 IDA     axon GO:0030424 ISO     vesicle GO:0031982 IDA     dendrite cytoplasm GO:0032839 IDA     neuron projection GO:0043005 ISO     perikaryon GO:0043204 IDA     synapse GO:0045202 IDA     basal dendrite GO:0097441 ISO     Schaffer collateral - CA1 synapse GO:0098685 ISO