Gene description for SH3BP5
Gene name SH3-domain binding protein 5 (BTK-associated)
Gene symbol SH3BP5
Other names/aliases SAB
SH3BP-5
Species Homo sapiens
 Database cross references - SH3BP5
ExoCarta ExoCarta_9467
Vesiclepedia VP_9467
Entrez Gene 9467
HGNC 10827
MIM 605612
UniProt O60239  
 SH3BP5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SH3BP5
Molecular Function
    protein kinase inhibitor activity GO:0004860 IBA
    protein kinase inhibitor activity GO:0004860 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IEA
Biological Process
    signal transduction GO:0007165 TAS
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IEA
    nuclear body GO:0016604 IDA
    cytoplasmic vesicle membrane GO:0030659 IDA
 Experiment description of studies that identified SH3BP5 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SH3BP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DST 667
Two-hybrid Homo sapiens
2 DISC1 27185
Two-hybrid Homo sapiens
3 MAPK10 5602
Reconstituted Complex Homo sapiens
4 IFT20 90410
Two-hybrid Homo sapiens
5 XPO1 7514
Affinity Capture-MS Homo sapiens
6 TNKS 8658
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 NAP1L2  
Two-hybrid Homo sapiens
8 Tnks  
Affinity Capture-MS Mus musculus
9 RAB11A 8766
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 ALB 213
Affinity Capture-MS Homo sapiens
11 LIMA1 51474
Affinity Capture-MS Homo sapiens
12 SOS1 6654
Two-hybrid Homo sapiens
13 TNKS2 80351
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 APP 351
Reconstituted Complex Homo sapiens
15 SPTBN1 6711
Two-hybrid Homo sapiens
16 NXF1 10482
Affinity Capture-RNA Homo sapiens
17 RNF146  
Affinity Capture-Western Homo sapiens
18 MOV10 4343
Affinity Capture-RNA Homo sapiens
19 MAPK9 5601
Reconstituted Complex Homo sapiens
20 EXOC1 55763
Two-hybrid Homo sapiens
21 RAB11B 9230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SYNE1 23345
Two-hybrid Homo sapiens
23 BTK 695
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
24 MAPK8 5599
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
25 CDC5L 988
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SH3BP5 is involved
No pathways found





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