Gene description for SH3BP5
Gene name SH3-domain binding protein 5 (BTK-associated)
Gene symbol SH3BP5
Other names/aliases SAB
Species Homo sapiens
 Database cross references - SH3BP5
ExoCarta ExoCarta_9467
Entrez Gene 9467
HGNC 10827
MIM 605612
UniProt O60239  
 SH3BP5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SH3BP5
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase inhibitor activity GO:0004860 IDA
    SH3 domain binding GO:0017124 IBA
Biological Process
    intracellular signal transduction GO:0035556 IDA
    negative regulation of protein tyrosine kinase activity GO:0061099 IBA
    signal transduction GO:0007165 TAS
Subcellular Localization
    mitochondrion GO:0005739 IEA
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified SH3BP5 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SH3BP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK8 5599
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
2 MAPK10 5602
Reconstituted Complex Homo sapiens
3 BTK 695
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 MAPK9 5601
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SH3BP5 is involved
No pathways found

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